Rajendar Mittapalli
Director, Clinical Pharmacology @辉瑞
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WORK HISTORY
Director, Clinical Pharmacology @辉瑞
San Diego, CA, US
EDUCATION
Texas Tech University Health Sciences Center
Doctor of Philosophy (Ph.D.), Pharmaceutical Sciences
Kakatiya University
Master's degree, Pharmaceutics
ABOUT RAJENDAR MITTAPALLI
SCIENTIFIC EXPERTISE:Research Expertise: One and two compartment pharmacokinetic modeling of drug distribution to brain in normal and pathological conditions such as brain tumors (primary glioma, metastatic tumors) using intravenous administration or brain perfusion model systems Good understanding of Pharmacokinetics and Pharmacodynamics, with strong knowledge of drug transport processes across biological membranes Tumor drug targeting using novel bioconjugate systems High throughput predictive computations and basic experiments to determine if a set of molecules may successfully move across the blood-brain barrier. Brain perfusions to determine the saturable kinetics of transport across the blood-brain barrier Documenting blood-brain barrier disruption in chronic models of potential neurodegeneration Pharmacokinetic modeling of solute and or drug movement at the blood-brain barrier during chronic nicotine exposure. Formulation development and process optimization of pharmaceutical dosage forms such as tablets and suspensionsComputer based modeling: Expertise in analysis of in vivo pharmacokinetic data using Phoenix WinNonlin. Compartmental and Non-Compartmental analysis of concentration-time data to estimate drug PK in plasma and tissues. WinNonlin based modeling of in vitro data to fit dose response curves as well as Michaelis-Menten kinetics to study interaction of drugs with transporters. Expertise in writing and solving differential equations for pharmacokinetic systems.
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