Rabih Gabriel
Scientist II, Biology at Mariana Oncology
- Role
- Sientist, Cell Biology at Alkermes
- Location
- Boston, MA, US
- LinkedIn followers
- 500 followers
About Rabih Gabriel
Cell Biologist with more than 20 years of industry experience working on anticancer drug…
Experience
Sientist, Cell Biology
Jun 2019 — Present · Waltham, MA, US
Established and maintained master and working cell banks of >250 human and mice tumor and neuronal cells, involving scale-up, banking of all cell lines as well as providing an electronic bank database implementing freezer pro and Benchling to streamline cell line inventory• Developed various drug resistant cell models from in vivo murine tissue cell culture in support of oncology work • Established hypoxia platform for oncology studies • Point person for outsourcing projects with multiple CROs • Designed and developed bespoke cell based and cell free assays in support of CNS, oncology, and immune-oncology cross functional groups • Performed subcloning, screening,(FACS, and various cell growth assays, Growth curve optimization, Clonogenic Plating Efficiency) to optimize cell lines used in all aspects of the company’s research• Oversaw all legal processes associated with cell line and reagent purchases for CNS, oncology research, and protein therapeutic groups• Optimized culture growth conditions (temp. CO2, media formulations), and cryopreservation formulations for Neuronal, cancer related cells and supported mass scale up processes for protein therapeutic groups for inhouse purification support• Established rigorous screens for all externally procured cell lines for mycoplasmas contamination using independent test methods (PCR, enzyme based.) • Directed and mentored junior scientists on routine cell culture and assay related work
Education
Worcester State University
Cell/Cellular and Molecular Biology
1995 — 1999
Skills
- Assay Development
- Cell Culture
- Drug Discovery
- Elisa
- Biotechnology
- Antibodies
- Biopharmaceuticals
- Biochemistry
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