Bertha K. Madras
Professor, Harvard Medical School (36 Years at Hms) @McLean Hospital
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WORK HISTORY
Professor, Harvard Medical School (36 Years at Hms) @McLean Hospital
Belmont, MA, US
19••••08: Created, Chaired Neurochemistry Division; 19••••14: Neurochemistry Laboratory NEPRC, Developed translational, basic research multidisciplinary program, integrating molecular, chemical, cellular, genetics, biochemical, behavioral, brain imaging methods. 2017-present: Director, Laboratory of Addiction Biology, McLean Hospital 1. Translational researcha. Actions of therapeutic and abused drugs in brainb. Attention Deficit Hyperactivity Disorder (ADHD): pathophysiology and genotype/phenotype associations. c. Parkinson’s disease: novel diagnostic markers and drug therapies 2. Basic research overall a. Neurobiology of psychostimulant drugs of abuse and psychotherapeutics: cocaine, cannabinoids, antipsychotics, anti-hyperactivity medications, anti-seizure medications.b. Drug discovery: novel drugs targeting monoamine transporters. c. Development of a new class of brain imaging agents for Parkinson\'s disease, ADHD, psychostimulant abuse, other applicationsd. Medications development for cocaine and psychostimulant addictione. Novel targets of stimulant and therapeutic drugs: trace amines and receptors f. Primate models of genetically-based human neuropsychiatric disorders: Genotype/phenotype associations, ADHD, opioids g. Adolescent susceptibility to MDMA, methamphetamine, THC or THC+CBD (marijuana). h. Neurotransmitter precursor entry into brain and dietary constituents.i. Brain distribution dopamine receptors/transporters. j. Mechanisms of a chemotherapeutic agent, asparaginase.Public Policy a. SBIRT effectiveness in federal programs (research)b. SBIRT promotion on national scale (policy)c. Drug use by youth (research)d. Parental marijuana use and offspring drug use (research)e. Vatican Pontifical Academy of Sciences (statement on Narcotics)f. World Health Organization (cannabis medical uses)Patents: 19 patents issued with collaborators; 27 international patents
EDUCATION
McGill University
PhD, Biochemistry
Massachusetts Institute of Technology
post-doctoral fellow 1967-1969; research associate 1972-1974, Neurobiology and Neurosciences
SKILLS
ABOUT BERTHA K. MADRAS
Professor of Psychobiology, Department of Psychiatry at Harvard Medical School. Director…
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