Paul McLean
Principal Scientist at Takeda (formerly Shire)
- Role
- Principal Scientist at Takeda
- Location
- Cambridge, MA, US
- LinkedIn followers
- 500 followers
About Paul McLean
PhD biochemist with extensive process development experience in the biotech industry. Analytical method development, qualification, and tech transfer to Quality Control for clinical trials of recombinant threapeutic proteins according to ICH Guidelines. Structure-function analysis for BLA readiness. Introduction of new microfluidic and Capillary Electrophoresis technologies for charge profile and purity analysis to Quality Control. Structure-function analysis for BLA readiness. Expertise in Host Cell protein detection and ELISA assay remediation. Technical support of cGMP investigations. Multi-disciplinary research experience in analytical methods, biochemistry, enzymology, cell biology, immunology and molecular biology.
Experience
Principal Scientist
Jan 2019 — Present · Lexington, MA, US
Education
University of Birminghan, England
Biochemistry
University of Sussex
DPhil (PhD), Biochemistry
Skills
- Recombinant Dna Technology
- Trace Protein Impurity Detection
- Gmp
- Western Blotting
- Protease Inhibitor Design
- Test Method Development
- Flow Cytometry
- Cell Signalling
- Antibody Characterization
- Analytical Support for Oos Gmp Investigations
- Cell Culture
- Nanopro
- Elisa
- Site-Directed Mutagenesis
- Gmp Testing
- Caliper Labchip
- Metalloprotein / Air-Senitive Protein Characterization
- Phage Display
- Biotechnology
- Sds-Page and Other Electrophoretic Methods
- Protease Substrate Design
- Protein Purification and Characterization
- Assay Development
- Cytokines
- Ich Compliant Method Qualification
- Cell Biology
- Enzyme Substrate Design
- Cell Based Assays
- Antibodies
- Protein Structure-Function Analysis
- Enzyme Mechanism
- Ice Charge Profile Analysis
- Enzyme Assay Development for Small Molecule Screening
- Biochemistry
- Capillary Electrophoresis
- Cze
- Microfluidic Ce-Sds
- Analytical Method Qualification
- Hcp Identification and Detection
- Imaging Capillary Electrophoresis
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