Paul Durfee
Director, RNA Therapeutics & Targeted Delivery | In Vivo CAR-T & Cell-Specific LNP Platforms
- Role
- Director at Sail Biomedicines
- Location
- Cambridge, MA, US
- LinkedIn followers
- 500 followers
About Paul Durfee
Director in RNA therapeutics and targeted delivery with 20+ years of academic and industry experience building and translating nanocarrier platforms.I currently lead formulation and delivery platform innovation at Sail Biomedicines, with a focus on targeted lipid nanoparticle (tLNP) technologies for in vivo CAR-T and cell-specific RNA delivery. My work centers on developing and scaling delivery systems that enable extrahepatic targeting and translational readiness across therapeutic programs.Previously at Janssen Pharmaceuticals, I led drug product development and served as CMC lead for an RNA LNP vaccine program, contributing to lead candidate selection and NME declaration. I continued to support the program as an SME for the Compound Development Team Leader (CDTL), partnering closely with discovery, analytics, process development, and CMC teams to translate early delivery concepts into development-ready platforms.My expertise spans lipid chemistry, bioconjugation, targeted delivery strategies, and RNA formulation and process development. I am motivated by opportunities to build durable delivery platforms, mentor scientific teams, and operate at the intersection of innovation and translation.
Experience
Director
Jan 2025 — Present · Cambridge, MA, US
Lead formulation and delivery platform development for targeted lipid nanoparticle (LNP) technologies supporting in vivo CAR-T and cell-specific RNA therapeutics.• Own strategy and execution of targeted LNP delivery platforms enabling extrahepatic RNA delivery.• Lead and mentor a multidisciplinary team across formulation design, screening, and optimization.• Partner cross-functionally with discovery, analytics, process development, and CMC to translate platforms toward development readiness.
Education
The University of New Mexico
Bachelor of Science (B.S.), Biochemistry
The University of New Mexico
Master of Science (M.S.), Nanoscience and Microsystems
The University of New Mexico
Doctor of Philosophy (Ph.D.), Biomedical Engineering
Skills
- Uv/Vis
- Fluorescence Microscopy
- Tga
- Fluorescence Spectroscopy
- Zeta Potential
- Optical Microscopy
- Live Animal Imaging (Ivis Lumina)
- Sonication
- Lyophilization
- Rotary Evaporator
- Controlled Atmosphere Glove Box
- Graphpad Prism
- Flowjo
- Living Image
- Axiovision
- Malvern Zetasizer Software
- Adobe Photoshop
- Adobe Illustrator
- Pymol
- Transmission Electron Microscopy
- Silica Nanoparticle Synthesis
- Chemical Conjugation
- Animal Models
- Mouse Models
- Immunization
- Suturing
- Blood Collection
- Injections (Iv, Im, Ip, Retro-Orbital, and Subcutanteous)
- Necropsy
- Tissue Processing
- Biosafety Level 2
- Pcr
- Rt-Pcr
- Protein Purification
- Elisa
- Mammalian Cell Culture
- Virus-Like Particle Synthesis
- Pcr Primer Design
- Project Planning
- Project Management
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