Paul Darby
Senior Bioinformatics Scientist @QuidelOrtho
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WORK HISTORY
Senior Bioinformatics Scientist @QuidelOrtho
San Diego, CA, US
Designed PCR primers for molecular diagnostic assays targeting infectious pathogens, optimizing sequences for specificity, amplification efficiency, melt temperature uniformity, and seamless integration into high-throughput diagnostic workflows to support rapid and reliable pathogen detection.Analyzed output data from Sanger and NGS sequencing runs, conducting quality control assessments, variant identification, sequence alignment reviews, and interpretive result analysis to validate assay performance, identify and resolve discrepancies.Developed custom Python-based bioinformatics toolchains and scripts to automate data processing pipelines, manage primer databases (including backend storage/logic and frontend interfaces for querying/access), streamline workflow efficiency, and enhance reproducibility across assay development and validation projects.
EDUCATION
California State University, Long Beach
Masters, Biochemistry
California State University, Long Beach
B.S., Biochemistry
ABOUT PAUL DARBY
Experienced bioinformatics and research scientist with 20+ years of expertise in molecular diagnostics, assay development, and computational tool creation. Strong background in server configuration, database administration, and development of genomic pipelines supporting diagnostic innovation. Specialized in real-time multiplex assay design, with extensive experience optimizing primers and targets for oncology, bacterial, and viral diagnostics—including 20+ years focused on Transcription-Mediated Amplification (TMA) and PCR-based assays. Proven ability to translate complex assay chemistry into computational frameworks, contributing to multiple on-market diagnostic products.Expertise includes NGS and RNASeq workflows to identify highly expressed transcripts, creation of in-silico tools for cross-reactivity and sequence similarity analysis, and mutational surveillance of pathogens such as SARS-CoV-2. Work supports molecular and antigen-based assays through rigorous data review and regulatory reporting.
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