Pasquale Piccolo
Assistant Investigator @Telethon Institute Of Genetics And Medicine Tigem
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WORK HISTORY
Assistant Investigator @Telethon Institute Of Genetics And Medicine Tigem
Pozzuoli, IT
EDUCATION
Università degli Studi di Napoli Federico II
Laurea in Biotecnologie Mediche
Università degli Studi di Napoli Federico II
Dottorato di ricerca, Riproduzione, sviluppo ed accrescimento dell'uomo
ABOUT PASQUALE PICCOLO
My career has been devoted to elucidating disease mechanisms of genetic diseases and developing of innovative therapeutic approaches. During my training, I gained extensive experience in the fields of liver inherited metabolic diseases and gene therapy. My primary research focus has been liver-directed gene therapy using helper-dependent adenoviral vectors and I worked extensively on vector-host interactions and strategies to improve the efficacy and safety of the vectors for human applications. Later in my training, my work has been focused on understanding the pathogenesis of liver disease due to α1-antitrypsin deficiency. My effort in this disease has also been successful and I published important findings about the disease in the high-impact journals. In 2019 I started my independent research activity on the development of novel liver-directed gene therapy approaches for genetic disorders characterized by liver fibrosis. I have been able to secure funding from European and US funding agencies and my research activity has also been recognized on both sides of the ocean by prestigious awards.
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