Nisha Sambamurthy
Translational Medicine Lead- Biomarkers - Hematology, Oncology, Immunology
- Role
- Translational Medicine Lead, Associate Director at AstraZeneca
- Location
- Belmont, CA, US
- LinkedIn followers
- 500 followers
About Nisha Sambamurthy
Translational Medicine lead with 9+ years of industrial experience across early and late stage programs, spanning TCEs, ADCs, small and large molecule therapies.Led translational efforts from preclinical through Phase shaping study design, dose‑selection, sequencing strategies with high‑impact pharmacodynamic datasets supporting key regulatory milestones.
Experience
Translational Medicine Lead, Associate Director
Jun 2022 — Present · South San Francisco, CA, US
Lead biomarker and translational strategy for CD20 targeting T‑cell engagers, BTK inhibitors, and AKT inhibitor programs in hematological malignancies (mainly lymphomas and leukemias)- Design and execute clinical biomarker plans aligned with program objectives, feasibility, regulatory expectations, and timelines- Guide platform selection (high-parameter flow cytometry, ELISA, MSD, ctDNA, proteomics, IHC) and evaluate technology readiness- Manage CRO/central lab assay development, transfer, validation, QC, and troubleshooting- Deliver biomarker data packages for regulatory interactions (FDA/EMA) and clinical decision‑making- Partner with Medical Affairs, Clinical Development, Regulatory, and Commercial teams to align scientific strategy.
Education
University of Pittsburgh School of Medicine
Ph.D, Pathology
2007 — 2014
Skills
- Murine Models of Disease
- Pulmonary Diseases
- Droplet Digital Pcr
- Stem Cells
- Western Blotting
- Immunofluorescence
- Mammalian Cell Culture
- Immunohistochemistry
- Qpcr
- Elisa
- Inflammation
- Real Time Pcr
- Osteoarthritis
- Primary Cell Isolation
- Microarray
- Flow Cytometry
- Copd
- Epithelial Cell Biology
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