Niels Rekers
Senior Principal Scientist, In Vivo Pharmacology at Pfizer
- Role
- Senior Principal Scientist, in Vivo Pharmacology at Pfizer
- Location
- Seattle, WA, US
- LinkedIn followers
- 500 followers
About Niels Rekers
SKILLS & QUALIFICATIONS• 15+ years of science experience in Cancer, Diabetes, and Obesity fields.• 11+ years of experience in design, development and implementation of in vivo models, including- In-house development of humanized mouse models expressing a functional and multilineage human immune system- Pharmacology, disease reversal and prevention, and behavior experiments- Design and validation of novel in vivo models- Development and utilization of transgenic mouse models.• 12+ years of experience as an immunologist, including the following studies- Immuno-oncology- and CAR T cell therapy development for treatment of solid and liquid pediatric cancers- Prognostic model development for outcome of kidney transplant rejection- Role of brain inflammation in pathogenesis of obesity and diabetes- Development of DNA-vaccine, nanoparticle, and cell-based immune-modulatory therapeutics for diabetes- Reversal and prevention of metastasis of breast- and prostate-cancer.• 8+ years of experience in cell biology, including in vitro and ex vivo polychromatic flow cytometry and cell cultures.• 7+ years of experience in genotyping studies, including qPCR, microarray and RNA-seq-based gene expression analysis.• Proficient in data analysis and visualization tools and statistical programs: BD Diva, FlowJo, GraphPad Prism, IBM SPSS statistics, ELN, and TIBCO Spotfire software packages.• Proficient in statistical methodologies, including: Logistic regression, Cox regression, Lasso regression, hierarchical and supervised clustering, ROC analysis, One- and Two-way ANOVA, Mantle-Cox test, Pearson χ2 test, Fisher exact test, Student’s t-test, Mann-Whitney U test, Bonferroni and Tukey post-hoc correction.• Experience with Python and R programming languages.
Experience
Senior Principal Scientist, in Vivo Pharmacology
May 2024 — Present · Bothell, WA, US
Education
Leiden University
Certificate Course on Laboratory Animal Science
2006 — 2007
Leiden University
Bachelor of Sciences, BSc, Biomedical Sciences
2004 — 2006
Leiden University
Master of Sciences, MSc, Biomedical Sciences
2006 — 2008
Leiden University
Doctor of Philosophy in Medicine, Outcome of Kidney Transplant Rejection
2008 — 2014
Hogeschool Leiden
Bachelor of Sciences, BSc, Biology and Medical Laboratory Research
2000 — 2004
Delft University of Technology
Health Physics Degree, level 5B
2002 — 2003
Hogeschool Leiden
Laboratory Animal Science Degree, article 12 WOD
2002 — 2004
Skills
- In Vitro
- Medical Research
- Kidney Transplant
- Statistical Genetics
- Transplantation
- In Vivo
- Immunohistochemistry
- Molecular Genetics
- Diabetes
- Immunology
- Molecular Biology
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