Nicholas B. Vera
Senior Scientist, Global Discovery and Development Sciences (Gdds) Dmpk Boston, Global Research @Novo Nordisk
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WORK HISTORY
Senior Scientist, Global Discovery and Development Sciences (Gdds) Dmpk Boston, Global Research @Novo Nordisk
Lexington, MA, US
Member of the Global Discovery and Development Sciences (GDDS) DMPK Boston group, within Global Research, performing HPLC-FD based PK analysis of siRNA therapeutics. Supported nonclinical bioanalytical studies to advance an siRNA program from Lead Candidate Selection (LCS) to First Human Dose (FHD) in 18 months. Performed bioanalysis method development and method qualification of oligonucleotide test articles in various matrices (e.g. plasma, liver, urine) from various animal models (e.g. mouse, NHP). Utilized Phoenix WinNonlin software to process and reduce PK data (e.g. non-compartmental analysis). Currently developing LC-MS/MS based methods for PK applications. Performed QC of bioanalytical data generated from nonclinical PK/PD studies used to inform and support programs entering the clinic. Authored bioanalysis reports from nonclinical PK/PD studies that were incorporated into IND filing submissions.
EDUCATION
Northeastern University
Master of Science (M.S.), Chemistry
Northeastern University
Doctor of Philosophy (PhD), Chemistry
Boston University
Bachelor of Science - BS, Biochemistry and Molecular Biology
SKILLS
ABOUT NICHOLAS B. VERA
I have 25 years of experience in small and large molecule mass spectrometry, 22 of which have been with pharmaceutical companies focused on cardiovascular and metabolic disease. Applications include: ADME, PK/PD, metabolite ID, oligonucleotide analysis, siRNA, RNAi, biomarker discovery, LC-MS and LC-MS/MS, GC-MS, DMS-MS/MS, lipidomics, metabolomics, QC, and high throughput screening. Specialties include small and large molecule analytics, principally the application of mass spectrometry. Experience in both biotech and pharmaceutical companies.Specialties: Mass spectrometry ion trap, Q-TOF, Orbitrap)High resolution accurate mass (HRAM) mass spectrometryDifferential mobility spectrometry-tandem mass spectrometry (DMS-MS/MS)Ion mobilityUPLC separation (Waters)HPLC separation (Waters, Agilent, Shimadzu)Reversed-phaseReversed-phase ion pairing chromatographyHILICNormal phase chromatographyLC-MS (Waters) LC-MS/MS (Waters, Sciex, Thermo)GC-MS (Agilent)GC-MS/MS (Agilent, Waters)Triversa Nanomate (Advion)High throughput robotic equipment (Tecan, Multi-mek, Bio-Mek)Metabolite IDsiRNARNAiBiomarker discoveryPK/PDADMEPurification and characterization of small molecules
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