Natalie Eyke
Chemical Engineering Senior Scientist at Vertex Pharmaceuticals
- Role
- Chemical Engineering Senior Scientist at Vertex Pharmaceuticals
- Location
- Boston, MA, US
- LinkedIn followers
- 500 followers
About Natalie Eyke
Chemical engineer with six years of experience in the pharmaceutical industry and…
Experience
Chemical Engineering Senior Scientist
Jul 2022 — Present · Boston, MA, US
Company-wide expert in applied machine learningo Prepared white papers, delivered presentations, and served as a consultant to educate colleagues about the mathematics of machine learning and guide its applicationso Developed a Bayesian optimization workflow to improve performance of proprietary roboticso Collaborated with a reaction kinetics expert to couple Bayesian optimization with a kinetic simulator to identify domains where Bayesian optimization is advantageous over DOEo Monitored literature to identify models relevant to process development and implemented them in-house, including tools for solubility prediction and reaction mechanism classification• Collaborated with cross-functional teams to support process development, scale-up, and manufacturing for two small molecule drug substances spanning Phase I through Phase Optimized a three-step synthetic procedure for higher end-to-end yield combined with purity and robustness upgrades while navigating limited starting material supply and accelerated project timeline by leveraging high-throughput experimentation and PAT, constructing models of reaction kinetics, and implementing Bayesian optimization and DOEo Managed technology transfer and provided rigorous technical oversight to enable six successful cGMP manufacturing campaigns at domestic and international CMOs that delivered a total of 200 kg of high-quality active pharmaceutical ingredients by combining strong communication skills with a trust-but-verify attitude and deep familiarity with the manufacturing plant environment• Constructed a fully-automated continuous reactor platform designed to enable closed-loop data-rich experimentation in flow. Recruited and managed an intern who validated and demonstrated the platform’s capabilities
Education
University of Michigan
Bachelor of Engineering (B.E.), Chemical Engineering
2010 — 2014
Massachusetts Institute of Technology
Doctor of Philosophy - PhD, Chemical Engineering
2017 — 2022
Skills
- Six Sigma
- Chemistry
- Matlab
- Hplc
- Aspen Plus
- C++
- Aspen Process Explorer
- Nmr
- Enginuity
- Jmp
- Nmr Spectroscopy
- Ir
- Aspen Process Graphics Editor
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