Mohammed Ghonime
Drug Discovery/Gene Editing and Cell Therapy/Non-viral drug delivery
- Role
- Senior Scientist- Io Drug Discovery and Cell Therapy at CRISPR Therapeutics
- Location
- Boston, MA, US
- LinkedIn followers
- 500 followers
About Mohammed Ghonime
Immuno-Oncology Expertise: Over 10 years of experience advancing immuno-oncology programs from early discovery through IND filing.Gene Editing Proficiency: Extensive hands-on experience with CRISPR/Cas9-mediated gene editing in primary immune cells, particularly T cells, enhancing therapeutic efficacy.Non-Viral Delivery Systems: Skilled in non-viral delivery methods, including lipid nanoparticle (LNP)-mediated in vivo editing of hematopoietic stem cells (HSCs), contributing to safer and more efficient gene therapies.Mechanistic Insights: Demonstrated ability to elucidate mechanisms of action, resistance pathways, and signaling cascades associated with antitumor agents in both in vitro and in vivo settings.Preclinical Model Expertise: Proficient in designing and executing preclinical studies, including functional assays, immune cell phenotyping, and the development of animal models to assess therapeutic efficacy.Cellular and Molecular Techniques: Expertise in immune cell isolation (magnetic sorting, FACS), cultivation, and functional characterization, along with proficiency in molecular and cellular biology techniques.Leadership and Mentorship: Proven track record of leading cross-functional teams, mentoring junior scientists, and fostering collaborative environments to drive scientific innovation.Scientific Communication: Experienced in authoring scientific protocols, research proposals, and regulatory documents, including IND reports, with strong communication and interpersonal skills
Experience
Senior Scientist- Io Drug Discovery and Cell Therapy
Jan 2023 — Present · Boston, MA, US
Education
The Ohio State University
PhD, Immunology
2010 — 2014
Helwan University Cairo
MSc, Immunology
2007 — 2007
Helwan University Cairo
Bachelor's degree, Pharmaceutical Sciences
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