Ming Yan
Senior Principal Scientist, Dx Sciences and Partnership, Novartis Precision Medicine at Novartis
- Role
- Senior Principal Scientist, Dx Sciences and Partnership, Novartis Precision Medicine at Novartis
- Location
- Cambridge, MA, US
- LinkedIn followers
- 500 followers
About Ming Yan
Principal Scientist and Tech Lead at Novartis Precision Medicine with 9 years + experience in the Clinical Trial Assay (CTA) and Companion Diagnostics (CDx) development. Familiar with drug and CDx submission strategies in the global and U.S. markets. Experienced in the preparation and meeting with the FDA. In depth knowledge in Next Generation Sequencing (NGS), multi-plex qPCR, digital droplet PCR (ddPCR), and various sample types including human FFPE tissue to plasma. Certified Green Belt of Design For Six Sigma (DFSS). Detail orients with strong trouble shooting skills. Excellent communication skilling with strong leadership and collaboration.CDx and CTA Strategies: • CDx strategies for drug submission• CTA strategies for patient enrollment in the clinical trial setting• Bridging between the CDx and CTA• Follow up CDx strategies Technologies: • Next generation sequencing (NGS)• Liquid Biopsy & ctDNA• Digital Droplet PCR (ddPCR)• Reverse-Transcription PCR (RT-PCR)• Fluorescent in situ hybridization (FISH)• Immunohistochemistry (IHC) Biomarker Analysis: • Accurate detection of biomarkers• Correlation between patient outcomes and biomarkers • Biomarker definition and cutoff • Co-occurrent mutations• Biomarkers for acquired resistance• Biomarker strategy for clinical trials and submissionsPartnership & Collaborations: • Partnership with external vendors for CDx development and approval• Partnership for follow up CDx• Study designs and contracts• Business relationship
Experience
Senior Principal Scientist, Dx Sciences and Partnership, Novartis Precision Medicine
Apr 2021 — Present · Boston, MA, US
Education
Harvard Medical School
Postdoctoral training, Microbiology and Vaccine Development
2001 — 2008
Skills
- Pcr
- Hplc
- Life Sciences
- U.s. Food and Drug Administration (Fda)
- Genomics
- Polymerase Chain Reaction (Pcr)
- Drug Discovery
- Qpcr
- Biochemistry
- Dfss Green Belt
- In Vitro
- Protein Chemistry
- Cell Biology
- Biotechnology
- Immunology
- Assay Development
- Cell Culture
- Molecular Biology
- Real-Time Polymerase Chain Reaction (Qpcr)
- Lifesciences
- Ngs (Next Generation Sequencing)
- Fda
- High-Performance Liquid Chromatography (Hplc)
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