Mick Knowles

Co-founder and Head of Reagent Development @Aboligo

Babraham, GB

AbOliGo (Cambridge UK, founded 2024) is developing a revolutionary platform for rapid, small-scale production of antibody-oligonucleotide conjugates (AOCs), addressing a critical bottleneck in multiplexing. AOCs are transformative tools that combine antibodies\' exquisite targeting specificity with oligonucleotides\' properties - DNA amplification and molecular barcoding, enabling unlimited multiplexing. However, while there are approximately 7 million commercially available antibodies, only ~0.03% are offered as AOCs.Recognizing the growing demand for AOCs, we aim to innovate and re-imagine the manufacturing process through three key technological advancements: Scale - A novel conjugation methodology that enables production at µg scale.Quality – Develop a QC quantitative release criteria, guaranteeing batch consistency.Fast – manufacture and deliver AOCs from a large portfolio within days.