Michelle Chan
Principal Research Associate Ii @Calico Life Sciences
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WORK HISTORY
Principal Research Associate Ii @Calico Life Sciences
Studied cellular senescence in vitro utilizing multi-omics approaches to capture changes in transcription, protein expression, chromatin state, and metabolism during the replicative lifespan of primary human fibroblast cells.• Cultured primary lung fibroblasts and sampled along its replicative lifespan for bulk RNA-seq, single cell RNA-seq, ATAC-seq, proteomics, and metabolomics• Analyzed and integrated data from metabolite, gene and protein expression data with R/RStudio • Modulated senescence related pathways using inhibitors, over-expression, and knockdowns of genes to study effects on senescenceCharacterize vascular calcification in mice by generating single cell transcriptomic maps to enable comparisons between diseased and normal mice• Generated first in-house single cell RNA-seq dataset from mouse aorta• Analyzed single cell RNA-seq data using the Cellranger pipeline and Seurat packageInitiated and developed in-house growth of intestinal and kidney organoids and characterized organoids with single-cell RNA-seq; study effects of age on organoid establishment • Optimized use of growth factors and small molecule inhibitors to generate mature, differentiated intestinal crypt organoids guided from published literature in the organoid field
EDUCATION
University of California, Davis
Bachelor's Degree, Biotechnology, Psychology
ABOUT MICHELLE CHAN
Biotech/pharma researcher with 15+ years of lab experience at big pharma and start-up environments-Expertise in cell biology, cell-based assay development, functional genomics, single cell transcriptomics-Proven excellent communication and teamwork skills through successfully leading large cross-functional projects-Passion and enthusiasm for learning new skills with track record of being an independent, fast learner
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