Michele Tedesco
Manager, Mrna Operations @Thermo Fisher Scientific
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WORK HISTORY
Manager, Mrna Operations @Thermo Fisher Scientific
Monza, IT
Accountable for end-to-end mRNA manufacturing operations, including RNAs synthesis, purification, and LNP encapsulation suites, supporting RNA-based Drug Substances and Drug Products (APIs, ATMPs) for both clinical and commercial supply.Lead an organization of ~50 FTEs across Manufacturing, MS & T, and Support functions, operating in a 24/7, multi-shift GMP manufacturing environment, ensuring robust execution, compliance, and operational resilience.Provide leadership across Manufacturing, MS & T, Maintenance & Calibration, with full accountability for technology transfer, process and cleaning validation, and operational readiness of complex mRNA manufacturing platforms.Drive operational performance, inspection readiness, and continuous improvement, enabling successful scale-up from early-stage manufacturing to sustained commercial operations in a highly regulated environment.Act as a key interface with Quality, Engineering, Supply Chain, and external stakeholders, aligning technical excellence with business priorities while fostering a strong culture of quality, ownership, and talent development.
EDUCATION
Università degli Studi di Napoli Federico II
Laurea magistrale in Biotecnologie Molecolari ed Industriali, Biotecnologie Molecolari ed Industriali
Università degli Studi di Napoli Federico II
Laurea in Biotecnologie Biomolecolari ed Industriali, Biotecnolgie Biomolecolari ed Industriali
Technische Universität Graz
Master's degree, Biotecnologie e Ingegneria Biochimica
ABOUT MICHELE TEDESCO
Senior manufacturing leader in the pharmaceutical and advanced therapies industry, with 12+ years of experience across Manufacturing, MS & T, Quality, Technology Transfer, and GMP Validation.I have led the end-to-end delivery of complex GMP manufacturing facilities, from early concept and design through construction, start-up, regulatory approval, and full operational ramp-up, supporting both clinical and commercial supply.Over the past 4+ years, I have operated at the forefront of Advanced Therapy Medicinal Products (ATMPs), with a strong focus on gene therapy, managing highly complex manufacturing operations in fast-growing, heavily regulated environments.With 10+ years of people leadership, I lead and scale cross-functional, high-performing teams, align technical excellence with business strategy, and build strong quality-driven cultures grounded in ownership, accountability, and continuous improvement.I am particularly effective in scaling operations, leading organizational transformation, and translating strategic vision into disciplined execution across manufacturing networks and start-up environments.
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