Mehabaw G. Derebe
Principal Scientist @Merck
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WORK HISTORY
Principal Scientist @Merck
South San Francisco, CA, US
o Biologics Characterization & Developability group lead - leading a group engaged in biotherapeutics characterization and analytics of a variety of modalities (mAbs, bi/multispecific antibodies, Antibody-Drug Conjugates (ADCs), fusion proteins, etc).o Developability sub-team leader for several pipeline projects of varied modality (bi/multispecific antibodies, Antibody-Drug Conjugates, fusion proteins, etc). Organizing and leading developability sub-teams mainly engaged in deep dives of drug developability data for lead candidates culminating with lead selection and involves representatives from several functions (cell line development and Bioprocess, CMC and Analytical Development, Formulation, etc).o Discovery Project/Team co-lead: Co-leading an early discovery Oncology project/team; target analysis, binder discovery, MOA & drug format selection, safety and efficacy study strategies, etc.o Team leadership and management - career planning and development, workload management, performance evaluations, experimental design, data compilation and analytics, project team presentations, group advocacy and representation, etc.o Contributing Project Team Member. Experimental design, generate, collate and present data in project teams and SLT meetings for lead selection discussions.o Core team member on several discovery projects in Oncology, Immunology, Neuroscience, CVM therapeutic areas.
EDUCATION
Addis Ababa University
MSc, BSc, Chemistry
UT Southwestern Medical Center
PhD, Molecular Biophysics
SKILLS
ABOUT MEHABAW G. DEREBE
Biophysicist/protein chemist with expertise in therapeutic antibody discovery and early developability assessment. Extensive experience in biophysical characterization (developability) of lead candidates, leading developability packages for a variety of projects, biophysical screening of early hits, leading project/team to discover and identify leads against a variety of targets, protein (antibody) reagent production, monoclonal/bispecific antibodies, Fc engineering and Fc receptor in-vitro assays.Background in structural biology (crystallography) of soluble and membrane proteins (ion channels).
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