Megan Warner
Associate Director at CRISPR Therapeutics | Molecular Biology and Protein Science R&D Expert | 8 yrs in Design and Production of Proteins and Antibodies, Biochemistry, Molecular Biology, and Gene Editing
- Role
- Associate Director at CRISPR Therapeutics
- Location
- Watertown, MA, US
- LinkedIn followers
- 500 followers
About Megan Warner
I’m a Protein Science, Biochemistry and Molecular Biology R&D specialist with over 8 years of experience driving innovation from concept to initial in vivo testing and IND-enabling studies. My work spans antibody discovery for cell therapies, preclinical assay development, and LNP targeting, protein bioconjugation, complex protein analytics, high-throughput cloning and antibody production, and novel gene editor engineering.I enjoy highly collaborative, fast-paced environments with clear goals and deep scientific rigor, where I can take an idea and help develop it into a viable therapeutic candidate. Over the years, I’ve gained wide technical expertise, as well as supported the growth of high-performing teams of junior researchers while managing multiple competing projects simultaneously to advance novel gene therapies from concept to in vivo testing. I love opportunities to connect with the biotech community to explore how we can innovate and transform medicine together.
Experience
Associate Director
Mar 2023 — Present · Boston, MA, US
Designing novel binders and overseeing antibody campaigns for targeted in vivo gene therapy.• Leading the Protein Science group (4 researchers) at CRISPR Therapeutics to produce proteins, Fc fusions, scFV, antibodies and Cas9 proteins of interest for the company• Subject matter expert on protein expression, purification, and analytics for the company• Authoring and reviewing research reports for IND submission for protein binders generated by the protein science team• Managing critical reagent antibody campaigns for research and IND-enabling applications• Leading a genome engineering team (3 researchers) to develop cell lines, assays, and lead editing reagents (guideRNAs, Cas9 encoding mRNAs, and LNP formulations) for an undisclosed liver disease• Designed, generated, and oversaw screening of ~700 different Cas9 mRNA constructs, resulting in 100-fold improvement in editing at a therapeutic target site
Education
Pomona College
Bachelor of Arts (BA), Chemistry
2006 — 2010
Massachusetts Institute of Technology
PhD, Biochemistry and Molecular Biology
2010 — 2017
Skills
- Data Analysis
- Pymol
- Fluorescence in Situ Hybridization
- Life Sciences
- Molecular Biology
- Protein Purification
- Western Blotting
- Molecular Cloning
- Biochemistry
- Teaching
- Assay Development
- Research
- Polymerase Chain Reaction (Pcr)
- Multi-Color Flow Cytometry
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