Max Foroutan
Principal Scientist @Prelude Therapeutics
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WORK HISTORY
Principal Scientist @Prelude Therapeutics
DE, US
EDUCATION
Universitat Autònoma de Barcelona
Ph.D., Biosciences
ABOUT MAX FOROUTAN
Extensive experience in production, purification, analysis, and quantification of:o Antibody drug conjugates (ADC)o Antibody oligonucleotide conjugates (AOC)o Degrader (PROTAC) antibody conjugates (DAC)o Biosimilaro Protein conjugate vaccineo Fluorescent dye protein conjugatesBioconjugation skills: o Small molecule drug conjugation to IgG1, IgG2, IgG4, and recombinant (VHH-Fc) antibodies.o Oligonucleotide functionalization and conjugation to antibodies.o THIOMAB conjugation.o Fluorescent dye, biotin and sulfo-tag protein conjugation.o Cysteine coupling (via Maleimide, Bromo-maleimide, SNAr, Re-bridging).o Lysine conjugation.o Enzymatic bioconjugation (transglutaminase).o Click-Chemistry site-specific bioconjugation.o Reductive amination, and derivatization via cross-linkers.o High throughput bioconjugation.Purification skills:o SEC, HIC, HILIC, RP, and IEX affinity chromatography (Agilent, Äkta, Biorad platforms).o Tangential flow filtration (TFF).o Removal of aggregates, free drug, endotoxin, unconjugated mAb.Analysis and Quantification skills:o Analytical chromatography.o Mass spectrometry (ESI-QTOF).o UV-Vis spectrophotometry.o DAR (DOL) calculation.Applied Assays:o BCA, Anthrone, TNBS, and LAL endotoxin level test.CEO award recipient for extraordinary contributions. Co-inventor on patent applications in preparation.Trained PhD and MS level chemists.
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