Matthieu Muffato
Informatics Infrastructure Team Lead @Wellcome Sanger Institute
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WORK HISTORY
Informatics Infrastructure Team Lead @Wellcome Sanger Institute
Cambridgeshire, GB
I lead the Informatics Infrastructure team for the Tree of Life programme. The team- implements large-scale genome analysis pipelines for faculty teams- maintains the production environment (application deployment and pipeline orchestration)- manages and curates metadata across our production systems.I arranged the team’s growth in two phases:1. Establish the core systems infrastructure and framework, hiring DevOps, software development, and bioinformatics staff.2. Expand capabilities for data curation, management, and analysis.My ambition is to provide the most efficient platform for assembling and analysing genomes at an unprecedented scale. The Tree of Life projects will generate tens of thousands of high-quality genomes in the coming years — more than have ever been sequenced. This is a challenging and exciting endeavour that will shape the future of biology.I’m especially proud to have introduced rigorous nf-core best practices (even extending the tooling) and Nextflow pipeline standards into the programme. I also helped shift our teams’ focus toward compute efficiency and green computing.We act as the interface between the Tree of Life teams (assembly production and faculty research) and Sanger’s IT teams, collaborating with informatics groups across other programmes. Our work spans assembly methods, genomics, comparative genomics, cloud computing, and large-scale analyses, with a strong emphasis on metadata tracking, quality control, and event recording. The team supports the “Genome Engine” from beginning to end.In parallel, I serve as Head of Informatics for Tree of Life. In this role I represent and support Tree of Life informatics within the Institute by ensuring sufficient IT capacity and policy compliance, and by drafting strategy and policy documents for the department, the Institute, and partner projects such as ERGA.
EDUCATION
Université Paris Cité
Bachelor of Science - BS, Mathematics
ensIIE
Engineer's degree, Computer science
Université Évry Paris-Saclay
Doctor of Philosophy - PhD, Bioinformatics
Lycée Louis-le-Grand
Mathematics, Physics
Université Évry Paris-Saclay
Master's degree, Bioinformatics
ABOUT MATTHIEU MUFFATO
Experienced informatics lead and developer, with a demonstrated history of managing teams and leading informatics projects. Skilled in programming, databases, genomics (PhD) and management. Team Lead at the Wellcome Sanger Institute. Worked at the European Bioinformatics Institute (EMBL-EBI) and the École Normale Supérieure (Paris).
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