Matthew Tonini
Senior Scientist Ii @Tango Therapeutics
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WORK HISTORY
Senior Scientist Ii @Tango Therapeutics
Boston, MA, US
Leveraging CRISPR context screening to identify and validate synthetic lethal oncology targets, driving these discoveries into a portfolio of therapeutic programs. My experience in a startup biotech, navigating funding needs and strategic partnerships, has fueled my growth within this clinical-stage company as its business functions expand.Advancing novel oncology programs:•Assay Development & Optimization: Designs, develops, and optimizes compound screening assays at scale, supporting a biotech organization of 100 people. Implements and refines high-throughput screening assays to assess pharmacodynamic properties, target engagement, and activity of novel small molecule inhibitors, impacting all company programs.•Mechanism of Action Studies: Conducts mechanism of action characterization and data analysis to support structure-activity relationship (SAR) development and drive compound progression for lead programs.•CRO Management & Technology Transfer: Collaborates with and manages various contract research organizations (CROs), facilitating assay and technology transfer to enhance program efficiency and productivity in multiple programs.•Communication & Collaboration: Effectively communicates updates and results within matrixed project teams and represents functional expertise in company-wide meetings.•Scientific Expertise & Development: Maintains current knowledge of oncology disease biology through literature searches, conference attendance, and academic coursework.
EDUCATION
University of Miami Miller School of Medicine
Doctor of Philosophy - PhD, Biochemistry and Molecular Biology
Harvard Extension School
Master’s Degree, Biotechnology
University of Massachusetts Amherst
Bachelors, Biology
SKILLS
ABOUT MATTHEW TONINI
Highly accomplished clinical research professional with an 18+ year R&D career, recognized for successfully translating scientific innovation into tangible results. Possesses a unique blend of technical mastery in cell-based and biochemical assay development, strategic planning expertise, and a collaborative approach to project management. Experience creating compelling presentations that highlight the company\'s science, technology, and market opportunity to investors and management. Adept at effectively partnering with CROs, ensuring meticulous resource documentation, and consistently driving drug discovery projects forward while fostering strong relationships with internal teams and external stakeholders.
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