Matteo Placidi

About Matteo Placidi

Dedicated analytical scientist experienced in the development of biotherapeutics, from preclinical to phase Track record of success delivering projects on time and budget. Effective communicator with experience publishing in top-tier scientific journals and international conferences, giving technical presentations to clients and in multi-departmental settings. Drug Development Experience • Lead a team of scientists in analytical method development, qualification, and physicochemical characterization of AAVs, fusion proteins, mAbs and ADCs and small molecules • CMC Program/analytical lead for candidates at different stages from pre-clinical to coordinating efforts of the various process development functions • Routine DS/DP release and stability testing to support several GMP manufacturing campaigns • Formulation design, forced degradation, solubility, and stability studies • Oversight of outsourced projects through CROs, CMOs and equipment vendors for method development and transfer • Experienced presenter: from invited talks at international conferences to project meetings involving clients and cross-functional teams of scientists • Authored CMC sections of IND filings, SOPs, experimental procedures, training and safety documents Technical Skills/Oversight • Detailed analysis of biologics: CE (CSDS, CIEF and CGE DNA), qPCR, potency, MFI, DSF, DLS and LCMS/MS peptide mapping & subunit analysis • Chromatography: IA, SEC, RP, HIC and IEX • Glycosylation: monosaccharide, sialic acid characterization and N-linked Glycan analysis • Synthesis, purification and formulation of antibody drug conjugates • LC-MS/MS characterization, detection and quantification of small molecule analytes • Solid state characterization: PXRD, optical microscopy and FTIR • Spectroscopy: UV/Vis, luminescence, and quantum yield• NMR: multi-nuclear, inversion recovery, spin echo, NMRD and VT• Analytical software: Empower, Chemstation, XCalibur, Pepfinder, Biopharmfinder, BioAnalyst, Class VP, Biospin, ACD NMR, PTI Felix, ChemDraw, PC and Mac OS, MS Office

Experience

1. Director, Analytical Development, Viral Vector Product Development

   Alexion Pharmaceuticals, Inc.

   May 2025 — Present · Cambridge, MA, US

Education

• The University of Manchester

  MChem, Chemistry (first class)

  2001 — 2005

• The University of Manchester

  PhD, Chemistry

  2005 — 2009

Skills

• Chemistry
• Organic Synthesis
• Organic Chemistry
• Dls
• Bioconjugation
• Inorganic Chemistry
• Chromatography
• Hplc
• Purification
• Ir
• Nmr
• Mass Spectrometry
• Chemdraw
• Protein Purification
• Spectroscopy
• Ftir
• Fluorescence
• Sds-Page