Marybeth G.

About Marybeth G.

Cross-functional project management experience in sustainability, lab expansion, shipping/receiving process improvements, safety culture, and performance. • Product launch and product design experience with a unique combination of lab operations management and benchwork. • First-hand validation of in vivo, ex vivo, and in vitro preclinical models in the areas of cancer, immunology, Alzheimer’s disease, Multiple Sclerosis, stroke, chronic kidney failure, nephropathy, arthritis, inflammatory bladder disease, pain, and treatment with small molecules, peptides, and immune-oncology candidates.• Working knowledge to design and build safe wet labs and animal facilities in start-up, medium, and global companies in compliance with OSHA, GLP, IACUC, USDA, and FDA guidelines.• Extensive working knowledge in vivarium and lab operations: developing training programs, establishing and managing vendor relationships, technology transfer, conducting risk management and disaster planning, sample distribution, import / export of biological material.• Imaging and Flow Cytometry: Fortessa X-20 (22 color with HTS) troubleshooting, maintenance, and panel design; bright field and fluorescence capture and imaging; histopathology processing; immunohistochemistry analysis; nanoparticle Nanosight NTA acquisition and analysis; drug delivery; establishment and maintenance of cancer cell lines.• Sample Preparation: Extracellular vesicle and exosome purification; exosome selection with magnetic beads from conditioned media and body fluids; fusion, electroporation, selection, and characterization of hybridoma cells for monoclonal antibody production; primary cell culture (PBMC, hippocampus, liver, spleen, lymph nodes); establishment and maintenance of cancer cell lines; blood sampling (i.p, p.o, s.c, i.v, and i.d.) and serum/plasma processing; planning and implementation of DMPK studies; rat surgery (stereotax, CNS ligation & post-operative pain); fixation; planning, implementation, and treatment of animal models of neurodegeneration, autoimmunity, chronic kidney disease, and osteoarthritis• Biological Assays: qPCR; RT-PCR; ChIP; SDS-PAGE, agarose gel, and bioanalyzer electrophoresis; ELISA optimization; LDH; cytokine release functional assays; chemiluminescence; Western Blot

Experience

1. Director, West Coast Site Operations and Managed Services

   Smartlabs

   Dec 2022 — Present · South San Francisco, CA, US

   Serves as the lead operational partner to the corporate team, managing the P&L and directing all site operations for a RSF life science facility to deliver high-quality lab and office environments and achieve net-positive member satisfaction.• Orchestrated the strategic transformation from a direct leasing business to a managed services model, guiding all change management activities for a smooth organizational transition.• Forecasted, manages, and optimizes a $3M operational and capital budget, reducing annualized spending by 3% through strategic vendor renegotiations and resource allocation.• Established and led monthly performance reviews for key stakeholders, synthesizing critical data on P&L, lab activity, safety, and quality (operational KPIs) to ensure strategic alignment and operational transparency.• Elevated team performance by establishing new standards and coaching, resulting in a 60% improvement in KPI first response and a 25% reduction in time to resolution. Promoted a proactive culture of safety across all laboratories.• Drove a major organizational turnaround in member experience, elevating the Net Promoter Score (NPS) by 100 points year-over-year and successfully shifting the score from net-negative to net-positive.

Education

• San José State University

  Master of Science - MS, Molecular Biology and Immunology

• University of California, Davis

  BS, Biological Sciences