Maryam Zangi

Staff Scientist @City of Hope

Los Angeles, CA, US

Designed and synthesized small molecules, prodrugs, and SAR analogs in support of AOH1996, a Phase I clinical trial candidate targeting caPCNA.• Executed retrosynthetic planning and route scouting strategies using heterocyclic chemistry, amide coupling, and parallel synthesis.• Collaborated with biology, pharmacology, and clinical research teams to validate compounds in preclinical models and cell-based assays.• Improved pharmacokinetic profiles, potency, and selectivity through iterative SAR exploration and prodrug development.• Contributed to patent filings, manuscript development, and abstract submission for the American Association for Cancer Research (AACR) conference.• Ensured compliance with cGMP guidelines and internal SOPs to maintain experimental integrity, safety, and reproducibility.

Southern Illinois University Edwardsville

Master's degree, Organic Chemistry

Saint Louis University

Doctor of Philosophy - PhD, Medicinal Chemistry

Aryamehr University of Technology

Bachelor of Science - BS, Chemistry