Markela Ibo Murphy

About Markela Ibo Murphy

Leadership of Drug Product Development (DPD) cross-group teams comprised of scientific experts; work with the senior functional leaders and the Chemistry, Manufacturing & Controls (CMC) Leader to ensure rapid identification and resolution of problems.• Lead the development of liquid and lyophilized formulations for multiple modalities in vial and PFS for therapeutic proteins.• Lead experiment design, coordinate execution/testing with formulation/analytical scientists, perform data analysis, and provide timely feedback.• Author and review regulatory documentation (IND, IMPD, CTA, IB, CSP) for clinical applications.• Experience with training and mentoring early-career scientists under a supervisory role.• Support due diligence for externalization/internalization of assets.• Subject matter expert for lyophilized forms, member of the Dry Dosage Form Expert working Group.• Structure and delegate work• Evaluate new technologies and made recommendations for application in industry.• Ensure leadership in the industry by participating in the external biologics formulation community through regularly publishing in peer reviewed journals, presenting at major conferences, and internal events.• Experienced leading and developing liquid and lyophilized dosage forms for monoclonal antibodies and proteins, some at high protein concentrations >100 mg/mL, for early and late-stage clinical products in vial and PFS.• Headed groups of 5-10 people to development formulations and enable DP.• Managed three contractors contributing to the development of high concentration,>300 mg/mL, lyophilized DP.• Establish and maintain strong relationships internally with other functions and externally with research organizations to develop and implement new technologies.

Experience

1. Senior Scientist

   AstraZeneca

   Aug 2021 — Present · US

Education

• The Johns Hopkins University

  Doctor of Philosophy - PhD, Chemical and Biomolecular Engineering

  2011 — 2017

• Aristotle University of Thessaloniki (AUTH)

  Bachelor’s Degree, Chemical Engineering

  2006 — 2011

• National Institute of Standards and Technology (NIST)

  Postdoctoral Fellow, Optimizing the biomanufacturing process of recombinant proteins

  2017 — 2018