Mahmoud Elazzouny
Director, Analytical Development and Bioanalysis @Nutcracker Therapeutics
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WORK HISTORY
Director, Analytical Development and Bioanalysis @Nutcracker Therapeutics
Establishing the mass spectrometry core within Nutcracker Therapeutics, that involved selection, purchase, site preparation, installation and maintenance process for the LC-MS systems- Developing analytical methods for the characterization of mRNA including capping and poly-A assays, LNP components, and small molecules using LC-MS, LC-MS/MS and HPLC- Developing analytical methods for modified proteins characterization and quantitation using top-down and bottom-up approaches- Training and leading a team of scientists performing analytical development activities and supporting method transfer to QC- Supporting delivery vehicle (DV) and proteins quantitation in biological tissues for PK and bio-distribution using LC-MS/MS- Supporting research and early development pipeline for DV and mRNA sequence selection and optimization - Supporting the design, conduction and interpretation of stability, impurity, degradation, extractable and leachable studies- Supporting the development of phase appropriate control strategies for raw materials, drug substance and drug product- Working cross functionally with Process Development, Manufacturing, Regulatory, Quality Assurance and Quality Control departments- Authoring and reviewing SOP, SAM, Qualification Protocol and reports for analytical methods- Authoring and reviewing analytical regulatory sections- Managing and guiding external CROs and solving analytical related challenges.
EDUCATION
University of Michigan
Doctor of Philosophy (Ph.D.), Analytical Chemistry
Utrecht University
Master degree, Pharmaceutical Sciences
ABOUT MAHMOUD ELAZZOUNY
Director | Analytical Development | Bioanalysis | Mass Spectrometry | RNA | LNP | Proteomics | Metabolomics @ Nutcracker Therapeutics | Ph.D., Analytical Chemistry
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