Luca Pagliaroli
Principal Scientist @GSK
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WORK HISTORY
Principal Scientist @GSK
Lead the use of advanced genomic technologies, including Next Generation Sequencing (NGS), Olink Proximity Extension Assay, NULISA, single cell analysis, qPCR, ddPCR to identify cellular biomarkers for patient stratification and drug response.Use of automatic liquid handlers (Hamilton Microlab STAR, SPT Dragonfly, SPT Mosquito) for NGS library preparation to accelerate sample processing and reduce TAT for cellular biomarkers identification for precision medicine and diagnostic portfolio.Collaborate with clinical biomarkers leaders to identify new technologies that can be used for drug target identification and validation.Serve as a technical expert in applied genomic technologies and generation of data to support the understanding of disease heterogeneity, drug’s mechanism of action, and patient response to treatment at the molecular level. Lead and manage genomics projects using external CROs.Conduct and oversee all aspects of the method development, troubleshooting, validation, and sample analysis for clinical studies requiring omics technologies.Ensure all work is conducted in compliance with GCLP regulations and follows the appropriate SOPs.
EDUCATION
Semmelweis University
Doctor of Philosophy - PhD, Theoretical Medicine
Alma Mater Studiorum – Università di Bologna
Master's degree (MSc), Pharmaceutical Biotechnology
Università degli Studi di Milano-Bicocca
Bachelor's degree (BSc), Molecular Biotechnology
SKILLS
ABOUT LUCA PAGLIAROLI
I started my scientific journey with a BSc in molecular biotechnology followed by a MSc in pharmaceutical biotechnology. I then pursued a PhD in molecular medicine as part of the prestigious Marie Skłodowska-Curie fellowship program (TS-EUROTRAIN Network). During my PhD, I studied Tourette Syndrome by using an omics approach trying to unravel the molecular network underlying the appearance of neurological disorders. I specialized also in the use of NGS data to identify and validate candidate drugs targets. As a Post-Doc at Thomas Jefferson University, I kept pursuing my interest in neurodevelopmental disorders. I focused on the SWI/SNF chromatin remodeling complex. In particular, I investigated the role of ARID1B in the appearance of Coffin-Siris Syndrome, Autism, and Intellectual Disabilities relying on pluripotent stem cells (iPSC) models and NGS data. As Clinical Genomic Scientist - Cancer R&D at The Children’s Hospital of Philadelphia, I used NGS technologies to develop new clinical tests to detect and monitor the progression of pediatric cancers. I am currently an Investigator Genomics at GSK where I am working on developing biomarkers for clinical trials. My main skills are: iPSC cell culture and differentiation, DNA/RNA extraction, rt-QPCR, ddPCR, Real Time PCR, NGS library preparation (RNA-Seq, ChiP-Seq, ATAC-Seq, RRBS-Seq), NGS data analysis, literature research, Western Blot, Flow Cytometry, mammalian cell culture, cell transfection, luciferase assay, Ingenuity Pathway Analysis, Drug Target Identification and Validation, SNP genotyping, animal handling and care, Illumina Sequencing, Liquid Biopsy, Methylation arrays, Illumina Infinium Genotyping Workflow.My Soft skills are: Innovation, Research, Analysis, Flexibility, Risk mitigation, Budgeting, Work Ethic, Mentorship, Project Management, Autonomy.Green Card Holder
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