Louise Hogg

Research Associate @University Of Bradford

Bradford, GB

I am focused on understanding the molecular mechanisms regulating modulations in glutamatergic synaptic transmission in the hippocampus.Long-term modulation in synaptic transmission, also termed synaptic plasticity, is thought to provide the molecular substrate that underlies learning and memory formation. We use a wide range of techniques including molecular and cell biology, biochemistry, immunocytochemistry combined with confocal imaging and electrophysiological recordings to study the mechanisms regulating endocytosis of glutamate receptors during synaptic plasticity.Understanding the molecular mechanisms underlying modulation in synaptic transmission has become very timely, as it will provide insights into normal and abnormal functioning of the brain and may find novel therapeutic targets to slow cognitive decline associated with ageing and neurodegenerative diseases.