Long Li

About Long Li

Highlights• Highly motivated scientist with strong expertise in discovery, development and application of high-affinity synthetic ligands and high throughput screening methods targeting leukemia cells.• Proven track record of innovation, authored 20 peer-reviewed journal articles in high-profile journals and presented in 3 conferences. Organized multi-task manager with excellent teamwork and collaboration skills demonstrated by managing 5 multifaceted biochemical research projects, resulting in the development of 4 collaborations.Specialties:• Strong technical expertise in chromatography-based separation (HPLC, LC-MS, TLC, column chromatography) and fluorescence-based detection, especially for the analysis of nucleic acids and membrane proteins;• Excellent hands-on skills in analytical chemistry techniques (UV-VIS, FT-IR, NMR, CD, fluorescence spectroscopy, high throughput screening), in-depth understanding of the basic principles underlying these techniques;• Demonstrated skills in molecular biology techniques (NGS library construction and sequencing, PCR, aptamer, gene knockdown/knockout, protein analysis, ELISA, FACS, gel electrophoresis, cell culture, confocal/fluorescence microscopy, viability and cytotoxicity assay);• Synthetic techniques: nanomaterial synthesis, oligonucleotide synthesis, small molecule organic synthesis;• Computer Languages: Python, AHK.Research• Developed a novel high throughput method by employing next generation sequencing and data mining and machine learning algorithm to increase the efficiency of measurement of aptamer binding ability to T-cell acute lymphoblastic leukemia.• Engineered aptamers to distinguish normal and disease cells both expressing a cancer biomarker PTK-7 to reduce drug toxicity to healthy cells and to improve therapeutic efficacy.• Integrating Cell-SELEX, aptamer affinity testing, and high-throughput sequencing to improve selection efficiency and shorten SELEX process to only one round.• Served as the lab manager and safety manager

Experience

1. Principal Scientist

   Intellia Therapeutics, Inc.

   Jul 2025 — Present · Cambridge, MA, US

Education

• Peking University

  Double major in Economics

• University of Florida

  Doctor of Philosophy - PhD, Chemistry

• Peking University

  Bachelor of Science - BS, Pharmaceutical Sciences