Liza Leshchiner
Computational Biology, Oncology, Immunology expert | AI/ML | People leader and team builder | Delivering innovation and impact.
- Role
- Associate Director Principal Scientist Ii, Immunology Computational Biology and Novel Therapeutics at AbbVie
- Location
- Cambridge, MA, US
- LinkedIn followers
- 500 followers
About Liza Leshchiner
My experience combines in-depth experimental expertise with computational biology knowledge. I have led multiple projects on target discovery and validation, as well as in-depth biological and biochemical oncogenic pathway interrogation.Computationally, my expertise is in cancer genome analysis, with a particular focus on single-cell and single-nucleus RNA sequencing to determine rare populations of tumor cells in patient tumors, cell-cell interactions including tumor-immune interactions, drug-responsive and resistant cell populations and their active pathways (python, single-cell tools such as scanpy, cellphoneDB, demuxlet, infercnv, scenic transcription factor inference, etc), bulk RNA sequencing (R packages such as limma, deseq2), and WES analysis.Experimentally, my scientific expertise is in drug discovery, cancer genomics, and cancer chemical biology. I performed high-throughput screens both in vitro and in cells, employed various therapeutic modalities (small molecules, stapled peptide therapeutic prototypes, RNA-based lipidoid formulations), collaborated with chemists on hit-to-lead optimizations, analyzed compound activities and target engagement, and optimized formulations for in vivo delivery. I designed and performed single-cell and bulk genomic experimental workflows and analyses on cell lines and patient samples. Beyond cancer, I\'ve worked in innate immune signaling and its targeting in inflammatory disease. On many of these projects, we directly collaborated with several leading biotech and pharma companies.
Experience
Associate Director Principal Scientist Ii, Immunology Computational Biology and Novel Therapeutics
Jan 2024 — Present
Computational biology, omics, AI/ML across Discovery Immunology, Biotherapeutics and Genetic Medicines, Precision Medicine, and Clinical Development programs. Pipeline support, innovative technologies, in-depth discovery analyses. We are part of the Genomics Research Center at AbbVie.
Education
Moscow State University
M.S. Summa Cum Laude
2001 — 2007
Harvard University
Ph.D., Chemistry and Chemical Biology
2007 — 2013
Massachusetts Institute of Technology
Laboratory of Dr. Robert Langer, Department of Chemical Engineering
2004 — 2006
Find verified contacts for anyone on LinkedIn
Unifers gives sales teams verified emails and direct dials, enriched profiles, and outreach that lands in the inbox.
Free plan included · No credit card required
This profile is compiled from publicly available professional sources. Unifers is not affiliated with or endorsed by LinkedIn. Request removal of this profile.