Lionel Sacconnay
Associate Director - Structural Bioinformatics @GSK
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WORK HISTORY
Associate Director - Structural Bioinformatics @GSK
Provide strategic and scientific leadership for computational antigen and mRNA design across viral, bacterial, and therapeutic programs.•Lead and mentor a multidisciplinary team of computational scientists, fostering innovation and high scientific standards; two team members received GSK excellence awards for innovation.•Drive integration of state-of-the-art AI tools (AlphaFold, ProteinMPNN, Boltz, Chai) into routine computational design workflows, significantly expanding in‑silico design capabilities for antigens, mRNA constructs, and platform components.•Serve as primary computational design partner for several programs, embedding design expertise within project teams & coordinating closely with immunology, molecular biology, development, and data science functions.•Advance portfolio assets, including-Bacterial antigen candidate progressed into development, with one patent submitted-Multiple mRNA‑based assets advanced through preclinical evaluation.•Shape the strategy for AI‑enabled T‑cell vaccine design, leading the implementation of a suite of advanced computational AI tools and embedding them into routine design toolbox to accelerate development of T-cell based vaccines.•Co-Lead cross‑organizational evaluation of AI aggregation and expression prediction and molecular dynamics tools providing scientific expertise to assess their value for integration into routine design workflows.•Partner with nucleotide sequence design specialists to guide mRNA sequence and structure optimization, ensuring alignment between antigen design, codon usage, and platform requirements.
EDUCATION
Université Joseph Fourier (Grenoble I)
Master of Science - MS, Medicinal Chemistry and Pharmaceutical Innovation
University of Geneva
PhD, In silico-driven strategies for the identification of novel sirtuin modulators., Pharmaceutical Sciences
Université Claude Bernard Lyon 1
Bachelor of Science - BS, Biochemistry and Molecular Biology
ABOUT LIONEL SACCONNAY
Computational design leader with 7+ years of experience driving protein, and nucleic‑acid design for next‑generation vaccines and therapeutics. Skilled in integrating structural, biochemical, and immunological insights with leveraging state‑of‑the‑art AI tools to engineer antigens and mRNA constructs. Proven ability to advance assets across viral, bacterial, and therapeutic portfolios, including one therapeutic candidate entering clinical testing and several vaccine candidates in preclinical evaluation. Recognized for building and leading high‑performing computational design teams and establishing active‑learning frameworks with experimental partners
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