Lian Zhou
Senior Director of Clinical Pharmacology at Arcus Biosciences
- Role
- Senior Director at Arcus Biosciences
- Location
- Indianapolis, IN, US
- LinkedIn followers
- 500 followers
About Lian Zhou
20 years of industry experience in drug discovery and development for both small molecules (primary) and large molecules. Experienced in oncology, immunology, neuroscience (pain), virology, and metabolic diseases. • Expertise in pharmacokinetics (PK), absorption, metabolism, distribution, and excretion (ADME), drug-drug interaction (DDI), and clinical pharmacology. • Have filed Investigational New Drug (IND), New Drug Application (NDA), and Biologics License Application (BLA) submissions for ADME and Clinical Pharmacology. • 14 years of experience in physiologically based pharmacokinetic (PBPK) modeling and simulation (SimCYP, GastroPlus). • Immunogenicity (IG) quantitative systems pharmacology (QSP) model assessment of IG and its impact on PK for large molecules. • IQ consortium member in pediatric PBPK modeling working group. • Management and oversight of CROs in the conduct of DMPK, toxicokinetics, and clinical pharmacology and bioanalytical studies. • Advise medicinal chemistry teams on complex DMPK issues. • Multi-tasking - sustained record of simultaneously supporting five compounds at once, even when one is NDA and another is BLA. • Leadership as Chairwoman (20••••12) and steering committee member(20••••13) of North Jersey Drug Metabolism Discussion Group. • Manager and mentor of research scientists.
Experience
Senior Director
Feb 2022 — Present
Department of Pharmacology
Education
University of North Carolina at Chapel Hill
Doctor of Philosophy (Ph.D.), Medicinal Chemistry
1996 — 2001
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