Kung-Hsien Ho

Scientist Ii @Biomea Fusion

San Carlos, CA, US

R&D in early discovery. Support lead selection and clinical trails. • Develop assays for diabetes research using isolated human pancreatic islets and clonal pancreatic cells. Focused directions include small molecules, Menin inhibitor, beta cell proliferation, and GLP-1 receptor signaling. Specialized in confocal microscopist.• Design & conduct in vitro, cellular, & ex vivo assays to support small molecules MOA studies, lead validation and optimization for diabetes, obesity, immunology, & oncology projects. • Develop in-house ex vivo human islet models and in vitro systems and collaborate with Medicinal chemistry team to optimize GLP-1r agonist leads in the type II diabetes/obesity project.• Study cytokine stimulated MHC-I expression to validate leads in the type I diabetes autoimmune disease project.• MOA studies using human myoblast differentiated myotubes to validate small molecules to promote myogenesis and muscle hypertrophy. • Jak-Stat signaling MOA studies using PBMC, THP1, and NK92 cells.• Coordinate projects with CROs to conduct kinome studies, peptide mapping, and protein-adduct formation. Responsible for assay design, sample preparation and QC using HPLC and mass spec, shipment coordination, and data analysis/interpretation.• Excellent documentation of protocols and notes. Wrote study reports for patent and IND applications.

National Taiwan University

Master of Science (MS)

National Taiwan University

Bachelor of Science (BS)

Indiana University Bloomington

Doctor of Philosophy (PhD)