Karl Manner

Associate Director at Sana Biotechnology

Role
Associate Director, Cell Therapy Process Development and Msat at Sana Biotechnology, Inc.
Location
South San Francisco, CA, US
LinkedIn followers
500 followers

About Karl Manner

Strategic CMC leader with a track record of building innovative, regulatory-compliant platforms for cell and gene therapies. Proven ability to scale teams, processes, and technologies in complex, fast-paced environments. Trusted leader in aligning technical innovation with business goals to drive patient access, platform expansion, and regulatory success across clinical stages.

Experience

  1. Associate Director, Cell Therapy Process Development and Msat

    Sana Biotechnology, Inc.

    Apr 2024 — Present · South San Francisco, CA, US

    Modeling and Control Strategy:Applied Design-of-Experiments (DoE) and mixed linear models to evaluate sources of process variability, informing the development of robust control strategies for clinical manufacturing. CMC Leadership:Designed and optimized a process for generating a genetically modified Master Cell Bank (MCB) for beta-islet differentiation, supporting CMC readiness for Type 1 Diabetes therapies. Supply Chain Intelligence:Developed raw material assessment and process control strategies to quantify supply risk and enable data-driven decision-making.Regulatory Authorship:Authored CMC sections for IND and INTERACT submissions, aligning technical content with evolving agency expectations. Technology Implementation:Identified, evaluated, and integrated novel bioprocessing technologies into GMP manufacturing, focusing on phase-appropriate implementation. Management:Managed a team of scientists and engineers, offering technical mentorship and career development opportunities.

Education

  • University of Washington

    Bachelor’s Degree, Bioengineering: Nanoscience and Molecular Engineering, Mathematics, Chemistry

Skills

  • Organic Chemistry
  • Microsoft Powerpoint
  • Python
  • Event Planning
  • Time Management
  • Matlab
  • Targeted Drug Delivery
  • Data Analysis
  • Microsoft Office
  • Communication
  • Polymer Chemistry
  • Social Media
  • Customer Service
  • Atrp
  • Mathematical Modeling
  • Chemistry
  • Microsoft Word
  • Nanotechnology
  • Public Speaking
  • Leadership
  • Research
  • Powerpoint
  • Microsoft Excel
  • Teamwork
  • Laboratory Skills

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