Krishna Ramajayam

About Krishna Ramajayam

PhD-trained scientist and investor with 3+ years in biotech industry R&D and 10+ years of experience in translational research, focused on proteins, nanoparticles, biomaterials, LNP systems, CMC, and high-throughput assays using automation. Proven track record of leading projects from concept to commercial launch, bridging wet-lab innovation, computational modeling, and field-based application science.Accomplishments:Led development of 5+ commercial platforms at Unchained Labs, including:A microfluidics-based LNP delivery system for proteins, mRNA, DNA, small molecules, and AAV, scaling from R&D to GMP-ready formatKnowledge about the drug development, protein binding assays and kinetics A DSF-based protein stability platform adopted by 10+ pharma clientsAn interferometry-based RNA detection assay that improved RNA detection sensitivity by 90% creating a new consumable product lineGene therapy ultrafiltration tool development to automate purification workflows for bioprocess clientsSupported 5 commercial product launches, contributing to a 200% increase in product revenue across three product lines by delivering Application notes, SOPs, and validation protocols enabling rapid adoptionCross-functional leadership and coordination across R&D, engineering, QA, and field serviceDeveloped in vivo and in vitro drug delivery systems at MUSC during post-doctoral research with liposomal nanoparticles using laser/microwave/ heating device activation, resulting in a 30-fold increase in targeted tumor drug accumulation.Applied COMSOL Multiphysics and MATLAB to simulate drug release kinetics, and predict PK profiles, reducing the need for iterative in vivo testing.Mentored 10+ graduate and postdoctoral researchers and organized 10+ career and training events through leadership roles in the MUSC Postdoctoral Association and National Postdoctoral Association.🧪 Technical Skills & Focus AreasDrug & Device Development: Biologics, LNPs, Gene Therapy, Protein Therapeutics, GMP Workflows, Scale-UpAssays & Analytics: Immunoassays (ELISA, Interferometry), fluorescence, Absorbance, DLS, Flow Cytometry, DSF, QC, Molecular biologyModeling & Simulation: COMSOL, MATLAB, PK Modeling, Heat/Mass TransferIn Vivo/In Vitro: Tumoral drug delivery, In Vivo Imaging.Field & Application Science: Technical Training, Instrument Implementation, Tech Transfer Open to: Senior/Principal Scientist, Field or Application Scientist, and Translational Development roles where I can drive innovation from concept to clinic. Based in the Bay Area | Open to relocation

Experience

1. Vice President of Technical Operations

   Oncoblaze

   Apr 2026 — Present · Charleston, SC, US

   I am leading the technical operations in a start up called Oncoblaze where we are developing a drug device combination to deliver chemotherapy and treat patients clinically

Education

• Shanmugha Arts, Science, Technology and Research Academy

  Bachelor of Technology (B.Tech.), Industrial Biotechnology

  2007 — 2011

• National Institute of Technology Rourkela

  Doctor of Philosophy (PhD), Biomedical Engineering

  2011 — 2017