Kirk Trisler
Head of Technical Operations at Bespoke Biotherapeutics
- Role
- Co-founder, Head of Technical Operations at Bespoke Biotherapeutics
- Location
- Alameda, CA, US
- LinkedIn followers
- 500 followers
About Kirk Trisler
Knowledgeable Biotechnology executive with 15+ years of CMC experience in product development and cGMP manufacturing. Proven track record advancing drug candidates from research through development and into the clinic.VP Manufacturing | Product DevelopmentEmail: k•••••••@gmail.comPossess expertise with novel, first-in-class therapeutics in collaboration with agencies.Experienced in research, process and analytical development, technical operations as well as technology transfers. Expertise in cGMP and CMC in Cell, Gene and Biologics Therapies. Thrives in a start-up environment that is ever-evolving and fast-paced. Experienced with international and boutique CMOs. Ability to conduct cost modeling and JMP tracking and trending. Skilled in creating and supporting complex cGMP supply chains and integrating in-house manufacturing with APIs, drug substances and drug product manufacturing.Core Competencies:• cGMP Manufacturing• cGMP Facility Design & Commissioning • Analytical Development• Process and Product Engineering & Development• Technology Transfer• CMO Management• Materials Management• Cost Modeling• JMP Analysis • Risk & Lean AnalysisAccomplishments:Re-initiated IND for world’s first hESC therapy Built and commissioned a sq ft cGMP biomanufacturing facility in a 2-year period.Generated adenovirus and LNP RNA vaccine processes and generated IND-enabling drug product in a 2-year periodSelected, contracted and managed niche and large international CMOs Led CMC efforts to support CIRM funded IND for hESC-derived cell therapy for strokePlease contact me: 65••••••47 with any Senior Level CMC, manufacturing or product development opportunities.
Experience
Co-founder, Head of Technical Operations
May 2023 — Present · San Francisco, CA, US
Bespoke Biotherapeutics was created to overcome obstacles to the effective natural immune response and limitations of currently approved immunotherapies against cancer by inventing novel, customized (i.e, bespoke)\"living drugs\" called engineered B-cell therapeutics.Bespoke is reprogramming human, peripheral blood-derived B-cells into intuitive \"living drug\" immunotherapies. Our unique anti-cancer platforms involve different combinations of engineered functions in order to target the particular needs of persons with specific solid tumor cancers and specific disease stages. Engineered functions can include specific tissue homing, tumor-associated antigen binding, tumor antigen presentation to T-cells, tumor reactive antibody secretion, immunomodulatory cytokine secretion, T-cell co-stimulation, and secretion of biomarker
Education
University of South Florida College of Medicine
Ph D, Immunology
Stanford University School of Medicine
Post-Doc, Radiation Oncology and Nuclear Medicine
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