Kiran Toti
Research Chemist @BioCryst Pharmaceuticals, Inc.
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WORK HISTORY
Research Chemist @BioCryst Pharmaceuticals, Inc.
Birmingham, AL, US
Small molecule drug discovery and development of components of complement system PPIIs.
EDUCATION
Karnatak University, Dharwad
Master of Science
Ghent University
PhD
JSS Banashankari Arts,Commerce & S.K.Gubbi Science College, Vidyagiri Dharwad
Bachelor of Science
National Institutes of Health (NIH)
Postdoctoral Fellow
SKILLS
ABOUT KIRAN TOTI
Medicinal chemist with extensive understanding and research experience in small molecule drug discovery from hit generation/ validation to lead optimization. • Designed molecules based on structure activity/ property relationships (SAR, SPR), and multi-parameter optimizations (MPO). • Discovery of modulators of Proteins, GPCRs, Ion-Channels, Kinases, Viral Polymerases, and Dynamins. • Collated and performed matrixed in vitro/ vivo DMPK-Tox data analysis, correlations and extrapolations. • Closely collaborated with cross functional teams while designing target compounds. • Working knowledge of computational tools for SBDD and MPO. • Worked at & with CROs/ external agencies to advance the projects. • Designed & executed multistep synthesis of heterocycles, nucleos(t)ides, carbohydrates, carbocycles, etc. • Purification and characterization of compounds using modern and classical techniques. • Managed personnel (interns to post-docs), instruments (NMR, LCMS, HPLC, etc.) and lab. • Proficient in technical writing, presentation and communication skills.
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