Kevin G. Hoff

Senior Director, Protein Engineering & Optimization @Metagenomi Therapeutics

Emeryville, CA, US

Managed strategic road mapping to drive new gene editing technologies from metagenomic sequences to preclinical assets, overseeing teams with 10 line reports and 20 project members to develop and execute high-throughput cloning, protein engineering, and system translation.• Championed operationalization of science activities, reducing silos between loosely affiliated collaboration groups to create matrixed teams with shared responsibility for delivering division goals; increased accountability, bolstered cohesion, and decreased time to complete key deliverables.• Spearheaded the implementation of Benchling, guiding project management from start to finish to create data capture workflows linking unique gene editor sequences to data outputs that enabled the training of AI models for various activities.• Led a team of five protein engineers in consolidating variant library build and screening operations to enable automated workflows, increasing throughput by over 10x and reducing costs by over 100x while generating large gains in editing efficiency across novel genome engineering.• Oversaw research, IP strategy, and deliverables across multiple project teams, developing the company’s next-generation editing systems capable of integrating cargoes larger than 4kbp.

Caltech

NIH Postdoctoral Scholar, Synthetic Biology / Protein Engineering

The Johns Hopkins University School of Medicine

HHMI Postdoctoral Fellow, Biophysics

UC Irvine

Ph.D., Biophysics and Biochemistry

California State University, Fullerton

B.A., Biology