Kevin G. Hoff
Research Leader | Program Management | Protein Engineering | Synthetic Biology
- Role
- Senior Director, Protein Engineering & Optimization at Metagenomi Therapeutics
- Location
- San Francisco, CA, US
- LinkedIn followers
- 500 followers
About Kevin G. Hoff
Innovative Biotechnology Leader with extensive experience leading operations, projects, and people in start-up and established organizations on both the research and business sides. Dedicated manager with a proven track record of building and overseeing large, cross-functional teams to design, engineer, and scale enzymes and organisms for industrial processes and human health. Dynamic change agent adept at driving process improvements to increase operational efficiencies and develop strategic pipelines. Energetic team player leveraging interpersonal and communication skills to build strong relationships across all levels of organizations as well as with strategic partners and investors, safeguarding alignment. Core competencies include:Strategic Planning * Technical Leadership * Relationship ManagementTeam Building & Leadership * Employee Development * Project Planning & ManagementResearch Innovation * Business Development * Intellectual Property Assessment & DraftingGoogle Scholar Link: & hl=en
Experience
Senior Director, Protein Engineering & Optimization
Jun 2023 — Present · Emeryville, CA, US
Managed strategic road mapping to drive new gene editing technologies from metagenomic sequences to preclinical assets, overseeing teams with 10 line reports and 20 project members to develop and execute high-throughput cloning, protein engineering, and system translation.• Championed operationalization of science activities, reducing silos between loosely affiliated collaboration groups to create matrixed teams with shared responsibility for delivering division goals; increased accountability, bolstered cohesion, and decreased time to complete key deliverables.• Spearheaded the implementation of Benchling, guiding project management from start to finish to create data capture workflows linking unique gene editor sequences to data outputs that enabled the training of AI models for various activities.• Led a team of five protein engineers in consolidating variant library build and screening operations to enable automated workflows, increasing throughput by over 10x and reducing costs by over 100x while generating large gains in editing efficiency across novel genome engineering.• Oversaw research, IP strategy, and deliverables across multiple project teams, developing the company’s next-generation editing systems capable of integrating cargoes larger than 4kbp.
Education
Caltech
NIH Postdoctoral Scholar, Synthetic Biology / Protein Engineering
The Johns Hopkins University School of Medicine
HHMI Postdoctoral Fellow, Biophysics
UC Irvine
Ph.D., Biophysics and Biochemistry
California State University, Fullerton
B.A., Biology
Skills
- Isothermal Titration Calorimetry
- X-Ray Crystallography
- Mammalian Cell Culture
- Yeast
- Circular Dichroism
- Biochemistry
- Protein Chemistry
- Protein Expression
- Fluorescence
- Molecular Biology
- Enzyme Kinetics
- Synthetic Biology
- Protein Engineering
- Biosensors
- Metabolic Engineering
- Project Management
- Strategic Planning
- Uv/Vis
- In Vitro
- Genetics
- Virology
- Biophysics
- In Vivo
- Protein Purification
- Biotechnology
- Cell Culture
- Life Sciences
- Purification
- Pcr
- Research and Development (R&D)
- Team Management
- Program Management
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