Ke H.
Data Science | Computational Biology | Bioinformatics
- Role
- Principal Scientist, Data Science at Innovent Biologics
- Location
- Washington, DC, US
- LinkedIn followers
- 500 followers
About Ke H.
My work concerns bioinformatics pipeline development & data management in the area of genomics and antibody discovery. Technical Skills- Expert in Python, R, Java, C/C++, shell script, Jupyter Notebooks, Django, MySQL, NoSQL, Neo4j, and Git/Bitbucket- Proven experience in analyzing and managing large-scale omics datasets including DNAseq, RNAseq, and GWAS data under HPC/AWS environment- Experienced in machine learning methods such as CNN, GAN, random forest, SVMs, Lasso regression, KNN clustering, and PCA- Experienced in distributed pipeline managers: snakemake and Nextflow- Proficient in exploratory data analysis, visualization, and result presentation- Familiar with Javascript, React.js, REST API, HTML5, CSS, and Singularity.
Experience
Principal Scientist, Data Science
Jan 2021 — Present · Washington, DC, US
Perform and supervise the analysis, visualization, and interpretation of omics datasets from TCGA, GTEx, and NCBI GEO to identify patterns, and correlations for bi-specific ADCs development and identify new indications for existing targets- Develop and apply computational algorithms and statistical models for data analysis and interpretation- Developing an NGS-based antibody high-throughput screening platform that clustered top leads with superior affinity and developability- Rational antibody design through analyzing NGS B-Cell repertoires to identify antibody candidates with high affinity and therapeutic efficacy- Guide and contribute to the development of data analysis pipelines and software tools.
Education
University of Pennsylvania
Master's degree
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