Katie Miller

WORK HISTORY

EDUCATION

ABOUT KATIE MILLER

As the Director of the Genomic Services core facility in the Institute for Genomic Medicine (IGM) at Nationwide Children\'s Hospital, I lead decision-making, resource establishment, and technology promotion internally and also represent the institute on a national stage with next-generation sequencing (NGS) vendors, providing early access testing and serving as a key opinion leader. My expertise is deeply rooted in my postdoctoral training in IGM from 20••••21 with Elaine Mardis, PhD, an internationally recognized pioneer in NGS-based human genomics. Before joining IGM, I was a researcher in the information technology department at Nationwide Children’s Hospital. There, I worked with colleagues to lead development of a bioinformatics tool (CardioGX) that allows researchers to upload and explore genome sequencing data and identify genetic variants that contribute to heart disease; this work earned me the title of a scientific “Wunderkind” by STAT magazine in 2017 (statnews.com/wunderkinds-2017/). Mastery of NGS methodologies demands not only a profound comprehension but also an intuitive grasp of when and how to deploy the technology effectively. Throughout my career, I have honed my expertise in NGS, leading scholarly initiatives and emerging as a sought-after authority among peers eager to adopt NGS technology in their own research. RELEVANT SKILLS:Computational and Analytical:Bioinformatics, Command Line / UNIX / LINUX, R programming, High Performance Computing in a Cloud Environment (SGE in AWS Cloud), running data analysis pipelines, next generation sequencing analysis (genome and transcriptome), data analysis and visualization; Data Analysis: Cancer genomics, somatic and germline variant analysis, ACMG variant interpretation, clinical genomics, human genetics.Next-Generation Sequencing (NGS): Generated RNA-Seq libraries using Illumina\'s TruSeq Stranded Total RNA and NEBNext UltraII Directional RNA and genome sequencing libraries using NEBNext Ultra II FS. Experienced loading NGS libraries on Illumina iSeq100 and MiniSeq. Single cell RNA sequencing; spatial transcriptomicsMolecular and Technical:DNA/RNA extraction and ensuing quality assessment via Agilent Bioanalyzer (RNA; nano and pico) as well as 4200 TapeStation, quantitative RT-PCR (SYBR), PCR / qPCR, cell culture, tissue culture, flow cytometry.