Julie Huang
Scientist Iii @Genentech
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WORK HISTORY
Scientist Iii @Genentech
South San Francisco, CA, US
Analysis of small molecule, ADC and peptide drug candidates using LC-MS/MS-Design and conduct in-vitro assays to address ADME related issues arising in drug discovery lead optimization-Perform hypothesis-driven plasma protein and tissue binding assays utilizing rapid micro-equilibrium dialysis to quantitate the amount of bound drug and unbound fraction-Conduct enzyme kinetic studies to determine definitive in-vitro clearance-Customize assays supporting drug binding, CYP inhibition, time-dependent inhibition, KI/kinact and metabolic stability assessment in various biological matrices to support various project needs-Support regulatory DDI studies to support IND submissions -Design and conduct CYP inhibition, time-dependent inhibition and KI/kinact IND-enabling studies-Prepare and author submission-ready reports for IND application-Develop and tailor LCMS methods to suit a diverse range of compounds-Perform compound optimization, method development, mobile phase preparation, sample analysis, system maintenance, and troubleshooting on LC-MS/MS systems: triple quadrupole mass spectrometers 5500, 6500+) and UPLC/HPLC systems (Agilent HPLC, Shimadzu UHPLC)-Utilize automation and liquid handling systems: V-11 BioCel, Oasis, and Tecan-Analyze data using DiscoveryQuant, MultiQuant, Analyst, ChemDraw, and Excel-Published a book chapter dedicated to protocols involving enzyme kinetic studies-Collaborate with teams and conduct training of new employees on assay performance, instrument operation and troubleshooting, and data analysis -Maintain inventory of various laboratory supplies and matrices-Attend conferences, seminars and workshops-Support outsourcing logistics and serve as a liaison between CROs and internal teams by coordinating compound shipment and data delivery and providing guidance and troubleshooting support
EDUCATION
University of California, Davis
Bachelor's Degree, Chemistry
SKILLS
ABOUT JULIE HUANG
I am a skilled analytical scientist with extensive experience in drug discovery and development, animal tissue/plant sample prep, rapid high-throughput analysis, and LC-MS/MS. I am experienced in chromatography method development and project management. I have strong communication, presentation and problem solving skills.Laboratory: Drug discovery and development, animal tissue and crop sample preparation for qualitative and quantitative analysis, perform rapid high-throughput analysis, SOPs, GLP and GDP, CTC Pal, HPLC, TLC, LCMS, GCMS, TOFMS, instrument troubleshooting, method development.Software: Microsoft Office, Adobe, Python, R, SPSS, Masshunter, WorkStation, ChemStation, Laura, ImageQuant, Radiochromatogram Generator, ChemDraw, Analyst, MultiQuant
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