Josy Augustine

WORK HISTORY

EDUCATION

SKILLS

ABOUT JOSY AUGUSTINE

My research interests are focused on examining the role of mRNA localisation in endothelial cells and investigating the potential of mRNA mislocalisation as a therapeutic target in endothelial cells to control undesired blood vessel formation in murine models of retinal neovascularisation. In addition, I am also undertaking pre-clinical evaluation of novel drugs and oligonucleotide therapeutics for the treatment of retinal neurodegeneration, inflammation and vascular dysfunction using both in vivo and in vitro models. My previous postdoctoral research explored the role of lipoxidation in the diabetic retina with special focus on neurodegeneration and vascular dysfunction. I also investigated novel treatments for Diabetic retinopathy by gene therapy and novel compounds using in vivo and in vitro functional techniques.During my PhD, I examined the role of Interleukin-33 (IL-33) and inflammation in Müller cells, and the role it plays in the pathogenesis of retinal degenerative diseases using in vivo models and in vitro models. My PhD titled \"The Role of Interleukin-33 in retinal degenerative diseases\" was submitted in 2019. Prior to my PhD, I completed a MSc in Biomedical Science from Ulster University, UK with an integrated work experience as a Research Scholar in Eugene and Marilyn Glick Eye Institute, Indiana, USA.I am a member of the Association for Research in Vision and Ophthalmology (ARVO) since 2017 and Diabetes UK professional member since 2020.