Joshua Close

Medicinal Chemist | Cross-Functional Team Builder | Inventor | Data-Visualization Enthusiast

Role: Associate Director at Blueprint Medicines
Location: Franklin, MA, US
LinkedIn followers: 500 followers

Research & DevelopmentView LinkedIn profile

About Joshua Close

Results-driven medicinal chemist and scientific leader with a proven track record of advancing small molecule drug discovery programs from target identification through clinical candidate nomination. Expert in cross-functional team leadership, patient-centric and collaborative culture building, and management of global CRO partnerships. Delivered clinical candidates including BLU-852 (tumor immunotherapy) and Numelvi® (JAK1 inhibitor) and played a key role in developing Blueprint’s kinase inhibitor platform. Recognized for resilience, innovation, and a commitment to delivering transformative therapies for patients.KEY SKILLSChemistry Program Team Leadership | Structure Based Drug Design | Hit-Finding Strategies | Lead Optimization | External CRO FTE Management | Target ID & Validation | HTS, Phenotypic & Virtual Screening | Cross-Functional Leadership | Patient-Centric & Collaborative Culture | Continuous Improvement | Data-Driven Decision Making | Patent Claims & ProceduresDEMONSTRATED IMPACT• Cross-Functional Leadership: Built and led high-performing, globally distributed teams integrating chemistry, biology, data science, and external CROs to accelerate candidate delivery. Managed up to 40 external FTEs across multiple programs and sites.• Program Advancement: Advanced multiple programs from target validation to lead optimization. Delivered BLU-852, an IND-ready MAP4K1 (HPK1) inhibitor for tumor immunotherapy, and co-discovered Numelvi®, a highly selective JAK1 inhibitor approved in the EU for use in dogs.• Platform Innovation: Key architect and leader in the development and enrichment of Blueprint’s proprietary kinase inhibitor platform, driving competitive advantage and enabling new target identification and validation.• Technology Enablement: Developed and deployed innovative data visualization and informatics tools to enhance research efficiency and insight.• Resilience & Culture: Fostered a culture of continuous improvement, operational excellence, and technology adoption. Demonstrated resilience in navigating program setbacks and evolving clinical landscapes.PUBLICATIONS:(PUBLICATION LIST)• Inventor on 16 Patent Applications• Co-authored 10 peer-reviewed journal articles & abstracts

Experience

Associate Director
Blueprint Medicines
Jan 2022 — Present · Cambridge, MA, US

Education

Skidmore College
Bachelor's degree, Chemistry

Contact information

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Current company

Blueprint Medicines

Biotechnology Research · 707 employees · Founded 2011 · Cambridge, Massachusetts, United States

Blueprint Medicines, a Sanofi company, is a fully integrated global biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including systemic mastocytosis and chronic urticaria, breast cancer and other solid tumors. Patients are at the center of our mission. We know that in order to make a difference in their lives, we must create an environment where our employees — also known as the Blue Crew — can do their best work. Our culture of transparency, curiosity and diversity empowers us to draw upon a wide range of backgrounds and perspectives to build a conscientious team dynamic. Ideas come from every member of the Blue Crew, from the executive team to new hires. Each day, our teams commit to approach one another with respect and trust: a simple promise that fosters an inclusive and collaborative spirit. We care deeply about the communities where we live and work, and we strive to make a profound impact where it matters most. Learn more about who we are and explore our career opportunities at https://www.blueprintmedicines.com/careers/. Read our community guidelines: https://www.blueprintmedicines.com/community-guidelines/.

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About Joshua Close

Experience

Associate Director

Education

Skidmore College

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