John Sinnamon
Associate Director of Preclinical Research @ Rett Syndrome Research Trust | PhD in Neuroscience
- Role
- Associate Director of Preclinical Research at Rett Syndrome Research Trust
- Location
- Cambridge, MA, US
- LinkedIn followers
- 500 followers
About John Sinnamon
Molecular biologist with a background in neuroscience and experience hiring and leading a cross-functional team of PhD and non-PhD level scientists in pre-clinical drug discovery programs beginning with target evaluation and identification through lead development. Responsible for establishing stage gate governance, internal and external collaboration coordination and CRO management. Highly effective at communication across multiple lines and levels within organizations and to external partners. Over 12 years of post graduate laboratory experience in studying rare diseases and developing viral, RNA and genomic editing based therapies for hepatic, immune, viral and neural targets. Responsible for entry and progression of multiple programs in the strategic portfolio as well as assay and platform development. Research has focused on rare diseases, epigenetic regulation and post-transcriptional regulation.Professional skills:Excellent organizational skills with the capability to successfully manage priorities across multiple projects. Ability to communicate effectively through presentations and publications to both a lay and expert audience. Experience establishing project plans and stage gates while managing risk. Demonstrated ability to build a successful team of scientists across multiple career stages.Technical skills:Genomic editing using nucleases, base editors, epigenetic editors, exogenous and endogenous RNA editors, in vivo delivery of viral vectors and oligonucleotides, siRNA based knockdown, high throughput screening in mammalian cells, primary cell culture of a variety of human cell types, in vivo characterization of mouse models, histology, microscopy, in situ hybridization, qPCR/ddPCR, ELISA, Western blot and flow cytometry.
Experience
Associate Director of Preclinical Research
Jun 2025 — Present
Education
Providence College
Bachelor of Science (B.S.), Biology, General
2004 — 2008
Stony Brook University
Doctor of Philosophy (PhD), Neuroscience
2008 — 2013
Skills
- Molecular Biology
- Western Blotting
- Cell Culture
- Fluorescence Microscopy
- Cell
- Confocal Microscopy
- Pcr
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