Jose Santana
Executive Director Operations IS - Manufacturing and Engineering at Amgen
- Role
- Executive Director Operations Technology- Manufacturing and Engineering at Amgen
- Location
- Beverly Hills, CA, US
- LinkedIn followers
- 500 followers
About Jose Santana
Seasoned technology and operations executive with extensive experience spanning manufacturing, corporate quality, and engineering information systems. I specialize in applying digital and data-driven technologies to enhance performance across the full manufacturing value chain—from drug substance to finished product.Recognized for driving innovation through clear strategic roadmaps and disciplined execution, I bring a track record of delivering results in diverse settings including startups, large-scale capital projects, and global manufacturing operations.I’m passionate about building strong, cross-functional partnerships and fostering alignment between IT, OT, and business stakeholders to accelerate transformation, strengthen quality, and create lasting business value.Key areas of expertise are:• Enterprise Quality Systems Capital Projects Management & Delivery • Manufacturing Operations Vendor Management • Advance Analytics & AI Data Historians • IT/OT Convergence Digital Manufacturing & Innovation• Cyber Security Enterprise Engineering Systems
Experience
Executive Director Operations Technology- Manufacturing and Engineering
Apr 2021 — Present · Thousand Oaks, CA, US
Accountable for Amgen’s global smart manufacturing strategy (I4.0), responsible for defining and executing the digital roadmap across manufacturing, quality, external supply, and engineering operations. Oversaw end-to-end IT/OT delivery for new facilities and lifecycle programs, while managing IT operations across U.S. commercial manufacturing sites and Singapore.• Accountable for the digital implementation of Amgen’s most digitally advanced facility in New Albany, OH—integrating automated material handling, predictive maintenance, secure networks, and AI-powered control tower dashboards—expanding capacity and driving new levels of operational efficiency.• Co-created and led the Digital Manufacturing Innovation Program, incubating cross functional (Q, PD, Mfg, SC) solutions such as predictive maintenance, smart dashboards, and KPI visualization using AI/ML, advance analytics, computer vision, wearable tech, and cloud technologies.• Directed a $150M–$200M/year IT/OT capital portfolio, modernizing digital infrastructure across global facilities and ensuring existing assets remain fit-for-purpose. Notable recent projects include Amgen Ohio, and Amgen North Carolina sites.• Led a multi-year,$100M Global Cyber Resilience Initiative to strengthen manufacturing operations against cyber threats.• Co-led the MES Standardization Program, harmonizing systems and practices to increase speed-to-market and operational efficiency.• Lead IT operations across U.S. commercial manufacturing and Singapore, fostering a culture of knowledge-sharing and people-centered leadership.• Achieved five-nines reliability for manufacturing systems and sustained >95% quarterly patching compliance—significantly improving system resilience and cybersecurity.
Education
University of Puerto Rico-Mayaguez
Bachelor of Engineering - BE, Computer Engineering
1986
Duke University - The Fuqua School of Business
Executive Program
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