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Jian-Guo Ren

Research Fellow @Dewpoint Therapeutics

Boston, MA, US
EMAILS
[email protected]
MOBILE NUMBERS
+91 *********19

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WORK HISTORY

Mar 2022 — Present

Research Fellow @Dewpoint Therapeutics

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Boston, MA, US

EDUCATION

1998 — 2001

Tsinghua University

Ph.D, Molecular, Cellular and Developmental Biology

2013 — 2013

Harvard Catalyst, Harvard Medical School

Certificate, Clinical Research Experience Training

SKILLS

Live Confocal for Hypoxia Area TrackingEnzymatic Isolation of Endothelial Cells and Fibroblast CellsCdna Library Construction and Expression CloningImmuno-OncologyDrug DiscoveryTumor ImmunologyAngiogenesis AssayHigh Throughput ScreeningOrgan Transplanting3d Spheroid-Based Drug ScreeningTumor Metabolism• Molecular Biology: Isolation and Manipulation of Dna and Rna; Dna Cloning andCrispr/Cas9 KnockoutTransmission Electron MicroscopeMetastasis Assay Using Mice Tail Vein InjectionSnp GenotypingCryo- and Paraffin-SectionGene Fusion and ExpressionSirna/Shrna KnockdownChipCancer Research• Animal Skills: Organ Transplanting; in Vivo Subcutaneous Tumor Model Using SciDigital Imaging MicroscopyMesc/Hesc/Ipsc/Tsc Growing and Differentiation InductionT/B/Mdsc Isolation and Function AssayRetrovirus/Lenti Virus Preparation and Transduction of Mammalian CellsFlow CytometrySurvival SurgeryIn Vivo/in Vitro Hypoxia AssayOral Infection PathogensTumor Cell and Fragment ImplantationBiomarker DiscoveryTumor-Infiltrating Lymphocytes Isolation and CultureCell Culture• Cell Biology: Cell Culture; Cell Transfection; Generate Stable Cell Lines; EnzWb/Ip/ElisaLuciferase AssayNude/Scid/Syngenic Mice/PdxTarget IdentificationIhc

ABOUT JIAN-GUO REN

Extensive experience in high-throughput screening (HTS) of large and small molecules, covering hit identification, lead optimization, and biomarker discovery for oncology, immuno-oncology, and rare disease-related drug discovery and development.• Strong expertise in preclinical and translational research, with a focus on designing proof-of-concept and mechanism-of-action (MoA) studies, as well as in vitro/in vivo preclinical pharmacology to support clinical development, utilizing in vitro cellular assays and various in vivo tumor models such as CDX, PDX, and syngeneic mouse models.• Deep expertise in building and managing research teams and leading cross-functional efforts from target identification to development candidate (DC) selection and IND-enabling studies across small molecules, ASOs, peptides, and antibodies.• Proven ability to oversee laboratory operations, mentor scientists, and manage external research collaborations with CROs and academic institutions to drive preclinical and translational research initiatives.

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