Jelena Mann
Chief Executive Officer @Fibrofind
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WORK HISTORY
Chief Executive Officer @Fibrofind
Newcastle upon Tyne, GB
EDUCATION
University of Southampton
Bachelor of Science (B.Sc.)
University of Southampton
Doctor of Philosophy (PhD), Medicine
SKILLS
ABOUT JELENA MANN
Liver fibrosis is a final common pathway of liver injury irrespective of aetiology. It is characterised by progressive replacement of normal hepatic tissue with collagen-rich scar tissue and is responsible for around 1.5 million death per annum worldwide. There are no proven effective therapeutics for fibrosis, the only treatment available for chronic liver disease is transplantation which is limited by availability of donor organs. I am interested in delineating epigenetic signalling pathways that trigger fibrogenesis and in doing so, discovering molecular control of fibrogenesis and associated signalling pathways that can be targeted with new as well as existing drugs. More recently we have also embarked on studies that test the ability of environmental factors to affect transgenerational inheritance of predisposition to liver fibrosis. Adaptation to environmental insults is critical for ensuring fitness and survival of the species, however it is currently not clear if predisposition to development of fibrosis exists or indeed if existence of disease in previous generations alters such predisposition. We have published the first report of the transgenerational epigenetic transmission of protection against liver fibrosis which provides evidence of heritable mechanisms for the rapid adaptation of animals to environmental insults. The lab is now carrying out further characterisation of this newly reported phenomena and its impact on liver disease of various aetiology.
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