Jeffrey Yang
Senior Scientist, Adc Chemistry @Hansoh Bio
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WORK HISTORY
Senior Scientist, Adc Chemistry @Hansoh Bio
MD, US
Played a pivotal role in designing and conjugating novel hydrophilic exatecan linker-payloads, co-leading a cross-site team to deliver a lead candidate and file a patent within 4 months of hire Enabled the nomination of a preclinical candidate (PCC) in a complex ADC program on an accelerated 8-month timeline (Feb–Sep 2025), showcasing efficiency, impact, and cross-functional teamwork Rapidly advanced the in-house development of novel linker-payload and site-specific conjugation platforms for efficient and reproducible production of next-generation, single- and multi-payload ADCs with improved biophysical properties (i.e, lower aggregation/hydrophobicity) Optimized ADC scale-up and purification processes to improve yield, reproducibility, and batch-to-batch consistency, delivering high-quality ADCs for preclinical studies (e.g, serum stability, PK/tox, in vivo efficacy) within proposed timelines
EDUCATION
Rutgers University
Doctor of Philosophy (Ph.D.), Medicinal Chemistry
Rutgers University
Doctor of Pharmacy (Pharm.D.), Summa Cum Laude
ABOUT JEFFREY YANG
I am a motivated, proactive synthetic medicinal chemist passionate about transforming molecules into medicines. With 8 years of experience in pharmaceutical discovery and development, I specialize in designing and constructing diverse drug-like molecules, from small molecules to peptides/macrocycles to XDCs, using creative drug design, modern med chem strategies, innovative synthesis, and structure-activity relationship (SAR) analysis. I also bring broad ADC expertise, spanning synthesis, payload-linker design, and bioconjugation, enabling me to manage end-to-end ADC discovery and development.As a licensed pharmacist, I leverage my deep understanding of PK/PD and physicochemical optimization to translate scientific insights into impactful drug development solutions, with a focus on oncology and infectious diseases.I also bring familiarity with process development, manufacturing, and quality controls, applying my synthetic chemistry skills to optimize processes for scalability, efficiency, and quality, further strengthening my impact across drug discovery and development. Key Highlights 1) Contributed to multiple oncology drug discovery and development programs : Identified a potent, drug-like immunomodulator targeting PD-L1 and led lead ID/optimization through in vivo PK and efficacy studies Discovered novel TOPO1i and hemiasterlin payloads with improved cytotoxicity and efflux resistance by driving in-house synthesis, optimization, and CRO collaboration Supported the development of a scalable prep-HPLC method that reduced linker-payload gelation and significantly improved purification yield Advanced linker-payload design and site-specific conjugation methods enabling single- and multi-payload ADCs2) Recognized across academia and industry for strong research excellence, cross-functional collaboration, and reliable, high-quality execution : 2 Outstanding Research Awards at the departmental and university-wide levels at Rutgers University A prestigious New Jersey Predoctoral Cancer Research Fellowship Award 2 CMC Project Special Awards at WuXi XDCI am committed to advancing pharmaceutical R&D through innovation and collaboration. Excited to connect and explore how we can collaborate to help tackle some of the toughest diseases in human health.
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