Jean-Luc Tran
Vice President Head of Biology & Pharmacology @Alphina Therapeutics
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WORK HISTORY
Vice President Head of Biology & Pharmacology @Alphina Therapeutics
New Haven, CT, US
ABOUT JEAN-LUC TRAN
Qualified scientist with over 15 years of industry experience. Focus on: Innate/adaptive immune responses: Immuno-Oncology/Targeted Oncology/Inflammatory diseases(SLE, RA,IBD,Lupus,Psoriasis, Atopic Dermatitis, Vitiligo, Alopecia Areata, Acnes, Fibrosis and H.S). Inflammation induces lipogenic, insulin resistance (Muscles/Fat/Liver-NAFLD/NASH-Fibrosis/CKD) and Pancreatic dysfunction Novel Inflammatory & diabetes targets identification-validation(insulin sensitizer/secretagogue/glucagon inhibitions).Experiences in GPCR Drug discovery. Regulation of energy and glucose homeostasis on inflammation/metabolic syndrome. Pancreatic islets Dysfunction/Impair of secretion, Apoptosis in access nutrients(glucotoxicity/lipotoxicity) and inflammation Preclinical animal models pharmacology(PK/PD to address Mechanism of Action, translation) Scientific cross functional collaboration/innovation Extensive experience in formulating and executing scientific strategy, building a portfolio of valuable pipeline products Serve as a Lead Principal pharmacology Identify/Collaborate with KOL Identify/Interface with academics collaboration. Leverage academics partner capabilities/Experience to help accelerate R&D Identify and set-up the contract and oversight CROs and Academics collaboration Specialties: ID Metabolic Syndrome and Immuno Oncology/Inflammatory Diseases targets, and POC Xenograft-Humanized Islets/Adipocytes/Immunology-rejection/toxicity,inflammatory, apoptosis In vivo expertise: PK/PD, MOA/ TE for TA: GTT, ITT, Hyperglycemic, Euglycemic CLAMP, tissues biomarker signaling (Glucose metabolism/fatty oxidation with radioactive tracers) Preclinical humanized-xenograft animal models development. Diabesity Targets Discovery: Fat/Liver/Muscle Metabolism, Insulin Resistance/IsletDysfunction; Insulin secretagogues and Hyper-Glucagonemic, Enteroendocrine biology-Incretins (GLP-1, GIP, PYY. Gut microbiota-short-chain free fatty acids) Rodent/large animal surgical skills Experience in Infectious/Inflammation/Cardiovascular diseases Immunohistochemistry/cells and Tissue Histopathology/immuno-assays Vascular Tissues Contractility Associates with Hypertension-Utilizing DMT Myograph System.
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